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Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey
Du, Yong1,2,3; Ding, Lu1,2; Na, Li1,2; Sun, Ting1,2,4; Sun, Xian5; Wang, Liqun5; He, Shulan5; Wang, Zhizhong5,6; Lu, Zhenhui1,2,6; Li, Feng7; Guo, Xiaofei7; Zhang, Yanhong7; Tian, Jin8; Wang, Bo9; Zhai, Sifan3; Yang, Chao3; Liu, Xiao3
2021-11-03
Source PublicationFrontiers in Cellular and Infection Microbiology
ISSN2235-2988
Volume11
Abstract

The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on gut microbiome in residents. Here we investigated the relation between living environment and gut microbiota in a homogenous population along an urban-rural gradient in Ningxia China. According to the degree of urbanization, the population is divided into four groups: mountainous rural (MR) represents non-urbanized areas, mountainous urban (MU) and plain rural (PR) represent preliminary urbanization, and plain urban (PU) is a representative of complete urbanization. Studies have found that with the deepening of urbanization, the prevalence of chronic diseases, such as diabetes, dyslipidemia, fatty liver, gallstones, and renal cysts, have gradually increased. The intestinal richness and diversity of the microbial community were significantly reduced in the PR and the PU groups compared with the MR and the MU groups. Based on linear discriminant analysis selection, the significantly enriched genera Faecalibacterium, Prevotella, and Pseudobutyrivibrio in the MR group gradually decreased in the MU, the PR, and the PU groups. Effect size results revealed that both residence and diet had an effect on intestinal microbiota. Our results suggested that the disparate patterns of gut microbiota composition were revealed at different levels of urbanization, providing an opportunity to understand the pathogenesis of chronic diseases and the contribution of the “rural microbiome” in potential protection against the occurrence of chronic diseases.

KeywordChronic Diseases Epidemiological Investigation Gut Microbiota Microbiome Urbanization
DOI10.3389/fcimb.2021.707402
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaImmunology ; Microbiology
WOS SubjectImmunology ; Microbiology
WOS IDWOS:000719837400001
Scopus ID2-s2.0-85119415693
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorDu, Yong
Affiliation1.Biobank, Laboratory of Surgery, General Hospital of Ningxia Medical University, China
2.Surgical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, China
3.College of Clinical Medicine, Ningxia Medical University, Yinchuan, China
4.Faculty of Health Sciences, University of Macau, Macao
5.School of Public Health and Management, Ningxia Medical University, Yinchuan, China
6.School of Public Health at, Guangdong Medical University, Dongguan, China
7.Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
8.Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, China
9.Department of Nursing, General Hospital of Ningxia Medical University, Yinchuan, China
Recommended Citation
GB/T 7714
Du, Yong,Ding, Lu,Na, Li,et al. Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey[J]. Frontiers in Cellular and Infection Microbiology,2021,11.
APA Du, Yong,Ding, Lu,Na, Li,Sun, Ting,Sun, Xian,Wang, Liqun,He, Shulan,Wang, Zhizhong,Lu, Zhenhui,Li, Feng,Guo, Xiaofei,Zhang, Yanhong,Tian, Jin,Wang, Bo,Zhai, Sifan,Yang, Chao,&Liu, Xiao.(2021).Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey.Frontiers in Cellular and Infection Microbiology,11.
MLA Du, Yong,et al."Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey".Frontiers in Cellular and Infection Microbiology 11(2021).
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