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Plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts
Guo, Lun Zhang1; Wu, Cheng Ham1; Tsai, Ming Fong2; Cheng, Fong Yu3; Shanmugam, Vijayakumar2; Tsai, Zen Uong1; Zhang, Zhiming4; Liu, Tzu Ming4; Yeh, Chen Sheng2
2021-11-01
Source PublicationApplied Sciences (Switzerland)
ISSN2076-3417
Volume11Issue:22
Abstract

Photodynamic therapy (PDT) provides a potential therapeutic approach for killing ma-lignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive photodynamic platform, providing maximum tissue penetration. Here, we present a gold nanopeanut platform exhibiting dual functions of NIR PDT and two-photon luminescence imaging. The nanopeanut with a size less than 100 nm exhibits two distinct NIR surface plasmon absorption bands at approximately 1110 and 1300 nm. To perform PDT, we conjugated commercial toluidine blue O (TBO) PS on the surface of the nanopeanuts. With spectral overlap, the 1230-nm femtosec-ond Cr: forsterite laser can excite the surface plasmons of nanopeanuts, transfer energy to TBO, and generate singlet oxygen to kill cells. Moreover, the plasmon resonance-enhanced two-photon luminescence of nanopeanuts can be used to map their delivery in vivo. These results demonstrate that the PS-conjugated gold nanopeanut is an effective theranostic system for NIR PDT.

KeywordAu Nanorod Fluorescence Resonance Energy Transfer Nanopeanut Photodynamic Therapy Two-photon Fluorescence
DOI10.3390/app112210875
URLView the original
Language英語English
Scopus ID2-s2.0-85119841578
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Department of Biomedical Engineering, National Taiwan University, Taipei, 10617, Taiwan
2.Advanced Optoelectronic Technology Center, Center for Micro/Nano Science and Technology, Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan
3.Department of Chemistry, Chinese Culture University, Taipei, 111, Taiwan
4.Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, Institute of Translational Medicine, University of Macau, 999078, Macao
Recommended Citation
GB/T 7714
Guo, Lun Zhang,Wu, Cheng Ham,Tsai, Ming Fong,et al. Plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts[J]. Applied Sciences (Switzerland),2021,11(22).
APA Guo, Lun Zhang,Wu, Cheng Ham,Tsai, Ming Fong,Cheng, Fong Yu,Shanmugam, Vijayakumar,Tsai, Zen Uong,Zhang, Zhiming,Liu, Tzu Ming,&Yeh, Chen Sheng.(2021).Plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts.Applied Sciences (Switzerland),11(22).
MLA Guo, Lun Zhang,et al."Plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts".Applied Sciences (Switzerland) 11.22(2021).
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