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Anti-hyperglycemic effects of refined fractions from cyclocarya paliurus leaves on streptozotocin-induced diabetic mice
Feng, Zheling1; Fang, Zhujun2; Chen, Cheng1; Vong, Chi Teng1; Chen, Jiali1; Lou, Ruohan1; Hoi, Maggie Pui Man1; Gan, Lishe3; Lin, Ligen1
2021-11-01
Source PublicationMolecules
ISSN1420-3049
Volume26Issue:22
Abstract

To identify the chemical components responsible for the anti-hyperglycemic effect of Cyclocarya paliurus (Batal.) Iljinsk (Juglandaceae) leaves, an ethanol extract (CPE) and a water extract (CPW) of C. paliurus leaves, as well as their total flavonoids (CPF), triterpenoids (CPT) and crude polysaccharides (CPP), were prepared and assessed on streptozotocin (STZ)-induced diabetic mice. After being orally administrated once a day for 24 days, CPF (300 mg/kg), CPP (180 mg/kg), or CPF+CPP (300 mg/kg CPF + 180 mg/kg CPP) treatment reversed STZ-induced body weight and muscle mass losses. The glucose tolerance tests and insulin tolerance tests suggested that CPF, CPP, and CPF+CPP showed anti-hyperglycemic effect in STZ-induced diabetic mice. Furthermore, CPF enhances glucose-stimulated insulin secretion in MIN6 cells and insulin-stimulated glucose uptake in C2C12 myotubes. CPF and CPP suppressed inflammatory cytokine levels in STZ-induced diabetic mice. Additionally, CPF and CPP improved STZ-induced diabetic nephropathy assessed by H&E staining, blood urea nitrogen content, and urine creatinine level. The molecular networking and Emperor analysis results indicated that CPF showed potential anti-hyperglycemic effects, and HPLC–MS/MS analysis indicated that CPF contains 3 phenolic acids and 9 flavonoids. In contrast, CPT (650 mg/kg) and CPC (300 mg/kg CPF + 180 mg/kg CPP + 650 mg/kg CPT) did not show anti-hyperglycemic effect. Taken together, polysaccharides and flavonoids are responsible for the anti-hyperglycemic effect of C. paliurus leaves, and the clinical application of C. paliurus need to be refined.

KeywordAnti-hyperglycemia Cyclocarya Paliurus Flavonoids Polysaccharides Triterpenoids
DOI10.3390/molecules26226886
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000724543400001
Scopus ID2-s2.0-85119612923
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorGan, Lishe; Lin, Ligen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Avenida da Universidade, 999078, Macao
2.Department of Clinical Pharmacy, Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China
3.School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Feng, Zheling,Fang, Zhujun,Chen, Cheng,et al. Anti-hyperglycemic effects of refined fractions from cyclocarya paliurus leaves on streptozotocin-induced diabetic mice[J]. Molecules,2021,26(22).
APA Feng, Zheling,Fang, Zhujun,Chen, Cheng,Vong, Chi Teng,Chen, Jiali,Lou, Ruohan,Hoi, Maggie Pui Man,Gan, Lishe,&Lin, Ligen.(2021).Anti-hyperglycemic effects of refined fractions from cyclocarya paliurus leaves on streptozotocin-induced diabetic mice.Molecules,26(22).
MLA Feng, Zheling,et al."Anti-hyperglycemic effects of refined fractions from cyclocarya paliurus leaves on streptozotocin-induced diabetic mice".Molecules 26.22(2021).
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