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Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo
Hou, Ying1,2; Liu, Rong3; Xia, Mengwei3; Sun, Chong1,2; Zhong, Bingling1,2; Yu, Jie1,2; Ai, Nana4; Lu, Jin Jian1,2; Ge, Wei4; Liu, Bo3; Chen, Xiuping1,2
2021-11-01
Source PublicationPharmacological Research
ISSN1043-6618
Volume173
Abstract

Colorectal cancer (CRC) is one of the most common causes of cancer-related death worldwide. Nannocystin ax (NAN), a 21-membered cyclodepsipeptide initially isolated from myxobacteria of the Nannocystis genus, was found to target the eukaryotic elongation factor 1A (eEF1A). The current study was designed to evaluate the anticancer effect and underlying mechanisms of NAN with in vitro and in vivo models. Results showed that NAN induced G1 phase cell cycle arrest and caspase-independent apoptosis in HCT116 and HT29 human CRC cells. NAN significantly downregulated cyclin D1 level in a short time, but NAN did not affect the transcription level and ubiquitin-dependent degradation of cyclin D1. Furthermore, NAN treatment directly targeted eEF1A and partially decreased the synthesis of new proteins, contributing to the downregulation of cyclin D1. Besides, NAN significantly suppressed tumor growth in the zebrafish xenograft model. In conclusion, NAN triggered G1 phase cell cycle arrest through cyclin D1 downregulation and eEF1A-targeted translation inhibition and promoted caspase-independent apoptosis in CRC cells.

KeywordApoptosis Cyclin D1 G1 Cell Cycle Arrest Nannocystin Ax
DOI10.1016/j.phrs.2021.105870
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000704159400016
Scopus ID2-s2.0-85115399981
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLiu, Bo; Chen, Xiuping
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, China
2.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, China
3.Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China
4.Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, China
First Author AffilicationInstitute of Chinese Medical Sciences;  Faculty of Health Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Hou, Ying,Liu, Rong,Xia, Mengwei,et al. Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo[J]. Pharmacological Research,2021,173.
APA Hou, Ying,Liu, Rong,Xia, Mengwei,Sun, Chong,Zhong, Bingling,Yu, Jie,Ai, Nana,Lu, Jin Jian,Ge, Wei,Liu, Bo,&Chen, Xiuping.(2021).Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.Pharmacological Research,173.
MLA Hou, Ying,et al."Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo".Pharmacological Research 173(2021).
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