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Pharmacological insights into autophagy modulation in autoimmune diseases
Wu, Ming Yue1; Wang, Er Jin1; Feng, Du2; Li, Min3; Ye, Richard D.4; Lu, Jia Hong1
Source PublicationActa Pharmaceutica Sinica B
AbstractAs a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed.
KeywordAutoimmune disease Autophagy Autophagy inducer Autophagy inhibitor Experimental autoimmune encephalomyelitis Inflammatory bowel disease Rheumatoid arthritis Systemic lupus erythematosus
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Scopus ID2-s2.0-85106314051
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 9999078, China
2.Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, 510000, China
3.School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510000, China
4.Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, the Chinese University of Hong Kong, Shenzhen, 518000, China
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Wu, Ming Yue,Wang, Er Jin,Feng, Du,et al. Pharmacological insights into autophagy modulation in autoimmune diseases[J]. Acta Pharmaceutica Sinica B,2021,11(11):3364-3378.
APA Wu, Ming Yue,Wang, Er Jin,Feng, Du,Li, Min,Ye, Richard D.,&Lu, Jia Hong.(2021).Pharmacological insights into autophagy modulation in autoimmune diseases.Acta Pharmaceutica Sinica B,11(11),3364-3378.
MLA Wu, Ming Yue,et al."Pharmacological insights into autophagy modulation in autoimmune diseases".Acta Pharmaceutica Sinica B 11.11(2021):3364-3378.
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