| Affiliated with RC | false |
| Status | 已發表Published |
| Pharmacological insights into autophagy modulation in autoimmune diseases | |
| Wu, Ming Yue1; Wang, Er Jin1; Feng, Du2; Li, Min3; Ye, Richard D.4; Lu, Jia Hong1 | |
| 2021-11-01 | |
| Source Publication | Acta Pharmaceutica Sinica B
 |
| ISSN | 2211-3835 |
| Volume | 11Issue:11Pages:3364-3378 |
| Abstract | As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed. |
| Keyword | Autoimmune disease Autophagy Autophagy inducer Autophagy inhibitor Experimental autoimmune encephalomyelitis Inflammatory bowel disease Rheumatoid arthritis Systemic lupus erythematosus |
| DOI | 10.1016/j.apsb.2021.03.026 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85106314051 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 9999078, China 2.Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, 510000, China 3.School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510000, China 4.Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, the Chinese University of Hong Kong, Shenzhen, 518000, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Wu, Ming Yue,Wang, Er Jin,Feng, Du,et al. Pharmacological insights into autophagy modulation in autoimmune diseases[J]. Acta Pharmaceutica Sinica B,2021,11(11):3364-3378. |
| APA | Wu, Ming Yue,Wang, Er Jin,Feng, Du,Li, Min,Ye, Richard D.,&Lu, Jia Hong.(2021).Pharmacological insights into autophagy modulation in autoimmune diseases.Acta Pharmaceutica Sinica B,11(11),3364-3378. |
| MLA | Wu, Ming Yue,et al."Pharmacological insights into autophagy modulation in autoimmune diseases".Acta Pharmaceutica Sinica B 11.11(2021):3364-3378. |
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