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Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
Cheng, Yaxin1; Zhao, Yonghua1,2; Zheng, Ying1
2021-12-01
Source PublicationChinese Medicine
ISSN1749-8546
Volume16Issue:1Pages:114
Abstract

With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment. Triptolide, the most potent bioactive compound from traditional Chinese herb Tripterygium Wilfordii Hook F, possesses immunosuppression and anti-inflammatory activity. It is a potential drug for the treatment of various autoimmune diseases, but its clinical application is still restricted due to severe toxicity. In this review, the pharmacodynamic effects and pharmacological mechanisms of triptolide in autoimmune diseases are summarized. Triptolide exerts therapeutic effect by regulating the function of immune cells and the expression of cytokines through inflammatory signaling pathways, as well as maintaining redox balance and gut microbiota homeostasis. Meanwhile, the research progress on toxicity of triptolide to liver, kidney, reproductive system, heart, spleen, lung and gastrointestinal tract has been systematically reviewed. In vivo experiments on different animals and clinical trials demonstrate the dose- and time- dependent toxicity of triptolide through different administration routes. Furthermore, we focus on the strategies to reduce toxicity of triptolide, including chemical structural modification, novel drug delivery systems, and combination pharmacotherapy. This review aims to reveal the potential therapeutic prospect and limitations of triptolide in treating autoimmune diseases, thus providing guiding suggestions for further study and promoting its clinical translation.

KeywordAutoimmune Diseases Pharmacodynamics Pharmacology Toxicity Triptolide
DOI10.1186/s13020-021-00525-z
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000716185100001
Scopus ID2-s2.0-85118754096
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhao, Yonghua; Zheng, Ying
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, University of Macau, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Recommended Citation
GB/T 7714
Cheng, Yaxin,Zhao, Yonghua,Zheng, Ying. Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity[J]. Chinese Medicine,2021,16(1):114.
APA Cheng, Yaxin,Zhao, Yonghua,&Zheng, Ying.(2021).Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity.Chinese Medicine,16(1),114.
MLA Cheng, Yaxin,et al."Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity".Chinese Medicine 16.1(2021):114.
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