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Adjunctive multi-session transcranial direct current stimulation for neurocognitive dysfunction in schizophrenia: A meta-analysis
Sun, Chen Hui1; Jiang, Wen Long2; Cai, Dong Bin3; Wang, Zhi Min4; Sim, Kang5; Ungvari, Gabor S.6,7; Huang, Xiong8; Zheng, Wei8; Xiang, Yu Tao9,10,11
2021-12-01
Source PublicationAsian Journal of Psychiatry
ISSN1876-2018
Volume66
Abstract

Findings of multi-session transcranial direct current stimulation (tDCS) as an adjunctive treatment of neurocognitive dysfunction in schizophrenia have been inconsistent. This meta-analysis of randomized controlled trials (RCTs) investigated the neurocognitive effects of adjunctive multi-session tDCS for schizophrenia. Twelve RCTs covering 418 schizophrenia patients were included and analyzed in this meta-analysis. The RevMan software (Version 5.3) was used to calculate risk ratios (RRs) and standardized mean differences (SMDs) with their 95% confidence intervals (CIs). Adjunctive tDCS outperformed the comparator in improving working memory deficits (SMD = 0.34, 95% CI: 0.03, 0.65; I = 52%; p = 0.03), but no significant effects were found in other cognitive domains. No group differences were found with regard to total psychopathology measured by the Brief Psychiatric Rating Scale and the Positive and Negative Symptom Scale (SMD =−0.29, 95%CI: −0.61, 0.03; I = 50%, p = 0.07) and discontinuation due to any reason (RR=0.80, 95%CI: 0.39, 1.66; I = 9%, p = 0.56). Adjunctive tDCS appears to have a significant therapeutic effect improving the working memory deficits in schizophrenia.

KeywordCognitive Impairment Schizophrenia Transcranial Direct Current Stimulation Working Memory
DOI10.1016/j.ajp.2021.102887
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000718275400004
Scopus ID2-s2.0-85118361926
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZheng, Wei
Affiliation1.Qingdao Mental Health Center, Qingdao University, Shandong, China
2.The Third People's Hospital of Daqing, Daqing, China
3.Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
4.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
5.West Region, Institute of Mental Health, Singapore, Buangkok Green Medical Park, Singapore
6.University of Notre Dame Australia, Fremantle, Australia
7.Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia
8.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
9.Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China
10.Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China
11.Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China
Recommended Citation
GB/T 7714
Sun, Chen Hui,Jiang, Wen Long,Cai, Dong Bin,et al. Adjunctive multi-session transcranial direct current stimulation for neurocognitive dysfunction in schizophrenia: A meta-analysis[J]. Asian Journal of Psychiatry,2021,66.
APA Sun, Chen Hui,Jiang, Wen Long,Cai, Dong Bin,Wang, Zhi Min,Sim, Kang,Ungvari, Gabor S.,Huang, Xiong,Zheng, Wei,&Xiang, Yu Tao.(2021).Adjunctive multi-session transcranial direct current stimulation for neurocognitive dysfunction in schizophrenia: A meta-analysis.Asian Journal of Psychiatry,66.
MLA Sun, Chen Hui,et al."Adjunctive multi-session transcranial direct current stimulation for neurocognitive dysfunction in schizophrenia: A meta-analysis".Asian Journal of Psychiatry 66(2021).
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