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Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice
Li, Ruilin1; Xue, Zihan1; Jia, Yanan1; Wang, Yajie1; Li, Shuqin1; Zhou, Jingna1; Liu, Junyu1; Zhang, Min2,3; He, Chengwei4; Chen, Haixia1
2021-12-01
Source PublicationInternational Journal of Biological Macromolecules
ISSN0141-8130
Volume192Pages:452-460
Abstract

Pancreatic lipase (PL) is a key enzyme related to the prevention and treatment of obesity. The aim of the study was to evaluate the inhibitory effects of mulberry leaf polysaccharides (MLP) on PL and possible interaction mechanism, inhibition on lipid accumulation in vitro and in vivo. The results revealed that MLP had obvious inhibitory effects on PL (P < 0.05). The interaction of MLP-PL complexes was in a spontaneous way driven by enthalpy, and hydrogen bonds were the main factors in the binding. MLP could significantly inhibit the development of lipid accumulation in HepG2 cells (P < 0.05). Furthermore, consumption of high-fat diet containing MLP showed protective effects on liver and adipose tissue damages in mice, and inhibited the lipid absorption in digestive tract. MLP also significantly reduced the increased expression level of pancreatic digestive enzymes (P < 0.05). The study indicated that the anti-obesity effect of MLP might be caused by inhibition of lipid absorption via reducing PL activity.

KeywordInteraction Mechanism Mulberry Leaf Polysaccharides Pancreatic Lipase
DOI10.1016/j.ijbiomac.2021.10.010
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000710860300008
Scopus ID2-s2.0-85116870762
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen, Haixia
Affiliation1.Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China
2.Tianjin Agricultural University, Tianjin, 300384, China
3.State Key Laboratory of Nutrition and Safety, Tianjin University of Science & Technology, Tianjin, 300457, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macao
Recommended Citation
GB/T 7714
Li, Ruilin,Xue, Zihan,Jia, Yanan,et al. Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice[J]. International Journal of Biological Macromolecules,2021,192:452-460.
APA Li, Ruilin,Xue, Zihan,Jia, Yanan,Wang, Yajie,Li, Shuqin,Zhou, Jingna,Liu, Junyu,Zhang, Min,He, Chengwei,&Chen, Haixia.(2021).Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice.International Journal of Biological Macromolecules,192,452-460.
MLA Li, Ruilin,et al."Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice".International Journal of Biological Macromolecules 192(2021):452-460.
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