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Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages
Wang, Qiaoqiao1,2,3; Zhang, Tian4; Ke, Chang Qiang1; Tang, Chunping1; Yao, Sheng1; Lin, Ligen4; Ye, Yang1,2,3
2021-12-01
Source PublicationPhytochemistry
ISSN0031-9422
Volume192
Abstract

Sesquiterpene lactones supply a variety of scaffolds for the development of anti-inflammatory drugs. In this study, eight undescribed guaianolides, i.e., lavandolides A‒H, were isolated from the whole plants of Artemisia codonocephala, together with five known analogues. Their planar structures and relative configurations were elucidated by spectroscopic measurements, and their absolute configurations were determined by electronic circulardichroism spectra and single crystal X-ray diffraction experiments. The nitric oxide inhibitory effect of all the isolates was assessed on lipopolysaccharide stimulated THP-1 macrophages. Lavandolide D showed a potent inhibitory effect on NO production, with IC values of 3.31 ± 0.74 μM. Furthermore, lavandolide D inhibited NOD-, LRR- and pyrin domain-containing protein 3 inflammasome-mediated interleukin-1β production through activating autophagy.

KeywordAnti-inflammation Artemisia Codonocephala Asteraceae Guaianolides Il-1β Nlrp3
DOI10.1016/j.phytochem.2021.112955
URLView the original
Language英語English
Scopus ID2-s2.0-85115183309
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
2.School of Life Science and Technology, ShanghaiTech University, Shanghai, 201203, China
3.University of Chinese Academy of Sciences, Beijing, No. 19A Yuquan Road, 100049, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, 999078, China
Recommended Citation
GB/T 7714
Wang, Qiaoqiao,Zhang, Tian,Ke, Chang Qiang,et al. Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages[J]. Phytochemistry,2021,192.
APA Wang, Qiaoqiao,Zhang, Tian,Ke, Chang Qiang,Tang, Chunping,Yao, Sheng,Lin, Ligen,&Ye, Yang.(2021).Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages.Phytochemistry,192.
MLA Wang, Qiaoqiao,et al."Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages".Phytochemistry 192(2021).
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