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Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing
Wang, Tian Long1; Zhou, Zi Fei1,2; Liu, Jun Feng1; Hou, Xiao Dong1; Zhou, Zhi1; Dai, Yun Lu4; Hou, Zhi Yong3; Chen, Feng1; Zheng, Long Po1,2
2021-12-01
Source PublicationJournal of Nanobiotechnology
ISSN1477-3155
Volume19Issue:1
Abstract

Background: Skin injury and the resultant defects are common clinical problems, and usually lead to chronic skin ulcers and even life-threatening diseases. Copper, an essential trace element of human body, has been reported to promote the regeneration of skin by stimulating proliferation of endothelial cell and enhance angiogenesis. Results: Herein, we have prepared a new donut-like metal–organic frameworks (MOF) of copper-nicotinic acid (CuNA) by a simple solvothermal reaction. The rough surface of CuNA is beneficial for loading/release basic fibroblast growth factor (bFGF). The CuNAs with/without bFGF are easily processed into a light-responsive composite hydrogel with GelMA, which not only show excellent mechanical properties, but also display superior biocompatibility, antibacterial ability and bioactivity. Moreover, in the in vivo full-thickness defect model of skin wound, the resultant CuNA-bFGF@GelMA hydrogels significantly accelerate the wound healing, by simultaneously inhibiting the inflammatory response, promoting the new blood vessels formation and the deposition of collagen and elastic fibers. Conclusions: Considering the superior biocompatibility, antibacterial ability and bioactivity, the CuNA and its composite light-responsive hydrogel system will be promising in the applications of skin and even other tissue regeneration. Graphic abstract: [Figure not available: see fulltext.]

KeywordCopper Hydrogel Metal–organic Frameworks Tissue Regeneration Wound Healing
DOI10.1186/s12951-021-01014-z
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000694888400001
Scopus ID2-s2.0-85114661893
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorHou, Zhi Yong; Chen, Feng; Zheng, Long Po
Affiliation1.Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China
2.Shanghai Trauma Emergency Center, Shanghai, 200072, China
3.Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China
4.Cancer Centre, Faculty of Health Sciences, University of Macau, 999078, Macao
Recommended Citation
GB/T 7714
Wang, Tian Long,Zhou, Zi Fei,Liu, Jun Feng,et al. Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing[J]. Journal of Nanobiotechnology,2021,19(1).
APA Wang, Tian Long,Zhou, Zi Fei,Liu, Jun Feng,Hou, Xiao Dong,Zhou, Zhi,Dai, Yun Lu,Hou, Zhi Yong,Chen, Feng,&Zheng, Long Po.(2021).Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing.Journal of Nanobiotechnology,19(1).
MLA Wang, Tian Long,et al."Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing".Journal of Nanobiotechnology 19.1(2021).
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