Residential College | false |
Status | 已發表Published |
The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy | |
Wang, Zhuo1,2; Zhao, Tingting1,2; Zhang, Shihui3; Wang, Junkai1; Chen, Yunyun1,2; Zhao, Hongzhou1,2; Yang, Yaxin4; Shi, Songlin2; Chen, Qiang5![]() ![]() | |
2021-12-01 | |
Source Publication | Biomarker Research
![]() |
ISSN | 2050-7771 |
Volume | 9Issue:1 |
Abstract | Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation is closely associated with tumor progression and poor prognosis in several tissues. Additionally, Wnt signaling also influences the tumor microenvironment and immune response. Some strategies and drugs have been proposed to target this pathway, such as blocking receptors/ligands, targeting intracellular molecules, beta-catenin/TCF4 complex and its downstream target genes, or tumor microenvironment and immune response. Here we discuss the roles of these components in Wnt signaling pathway in tumorigenesis and cancer progression, the underlying mechanisms that is responsible for the activation of Wnt signaling, and a series of drugs targeting the Wnt pathway provide multiple therapeutic values. Although some of these drugs exhibit exciting anti-cancer effect, clinical trials and systematic evaluation should be strictly performed along with multiple-omics technology. |
Keyword | Beta-catenin Drug Development Epigenetic Modification Tumor Microenvironment Wnt Signaling |
DOI | 10.1186/s40364-021-00323-7 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Oncology ; Research & Experimental Medicine |
WOS Subject | Oncology ; Medicine, Research & Experimental |
WOS ID | WOS:000694231900003 |
Scopus ID | 2-s2.0-85114289909 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Faculty of Health Sciences |
Corresponding Author | Liu, Kuancan |
Affiliation | 1.Central Laboratory, Xiang’an Hospital of Xiamen University, Xiamen, 361102, China 2.School of Medicine, Xiamen University, Xiamen, 361102, China 3.Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, EH164UU, United Kingdom 4.Department of Biology, University of Rochester, Rochester, 14627, United States 5.Cancer Centre, Faculty of Health Sciences, University of Macau, Macao |
Recommended Citation GB/T 7714 | Wang, Zhuo,Zhao, Tingting,Zhang, Shihui,et al. The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy[J]. Biomarker Research,2021,9(1). |
APA | Wang, Zhuo,Zhao, Tingting,Zhang, Shihui,Wang, Junkai,Chen, Yunyun,Zhao, Hongzhou,Yang, Yaxin,Shi, Songlin,Chen, Qiang,&Liu, Kuancan.(2021).The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy.Biomarker Research,9(1). |
MLA | Wang, Zhuo,et al."The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy".Biomarker Research 9.1(2021). |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment