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The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy
Wang, Zhuo1,2; Zhao, Tingting1,2; Zhang, Shihui3; Wang, Junkai1; Chen, Yunyun1,2; Zhao, Hongzhou1,2; Yang, Yaxin4; Shi, Songlin2; Chen, Qiang5; Liu, Kuancan1,2
2021-12-01
Source PublicationBiomarker Research
ISSN2050-7771
Volume9Issue:1
Abstract

Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation is closely associated with tumor progression and poor prognosis in several tissues. Additionally, Wnt signaling also influences the tumor microenvironment and immune response. Some strategies and drugs have been proposed to target this pathway, such as blocking receptors/ligands, targeting intracellular molecules, beta-catenin/TCF4 complex and its downstream target genes, or tumor microenvironment and immune response. Here we discuss the roles of these components in Wnt signaling pathway in tumorigenesis and cancer progression, the underlying mechanisms that is responsible for the activation of Wnt signaling, and a series of drugs targeting the Wnt pathway provide multiple therapeutic values. Although some of these drugs exhibit exciting anti-cancer effect, clinical trials and systematic evaluation should be strictly performed along with multiple-omics technology.

KeywordBeta-catenin Drug Development Epigenetic Modification Tumor Microenvironment Wnt Signaling
DOI10.1186/s40364-021-00323-7
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000694231900003
Scopus ID2-s2.0-85114289909
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLiu, Kuancan
Affiliation1.Central Laboratory, Xiang’an Hospital of Xiamen University, Xiamen, 361102, China
2.School of Medicine, Xiamen University, Xiamen, 361102, China
3.Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, EH164UU, United Kingdom
4.Department of Biology, University of Rochester, Rochester, 14627, United States
5.Cancer Centre, Faculty of Health Sciences, University of Macau, Macao
Recommended Citation
GB/T 7714
Wang, Zhuo,Zhao, Tingting,Zhang, Shihui,et al. The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy[J]. Biomarker Research,2021,9(1).
APA Wang, Zhuo,Zhao, Tingting,Zhang, Shihui,Wang, Junkai,Chen, Yunyun,Zhao, Hongzhou,Yang, Yaxin,Shi, Songlin,Chen, Qiang,&Liu, Kuancan.(2021).The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy.Biomarker Research,9(1).
MLA Wang, Zhuo,et al."The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy".Biomarker Research 9.1(2021).
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