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Pharmaceutical Technology Licensing: An Analysis in the Field of Cardiovascular Disease
Ni J.1; Wan J.1; Kong X.1; Cai Y.1; Yang F.2; Wang Y.1; Hu Y.1
Source PublicationJournal of Pharmaceutical Innovation

The technological flows and licensing across institutions plays an essential role in the process of pharmaceutical innovation by integrating the competing resources of different institutions and sharing the costs and risks, especially in the current era of open innovation. This article aims to generally describe technology licensing activities on cardiovascular drugs and, based on visualizing technology flows at different stages, to further investigate the multistage leading performers and their licensing strategies. From the IMS R&D Focus, a world-leading database in the healthcare industry, the research sample comprises 632 licensing inventions for cardiovascular drugs from 1980 to 2014. Furthermore, a network-based approach is employed to visualize the technology flows by setting nodes to represent licensing institutions and edges for licensing behavior, and further to analyze institution leaders and licensing strategies through various indicators, e.g., out-degree, in-degree, and betweenness centrality. The results show that technology licensing networks gradually transformed from sparse to dense from the preclinical to marketed stages. There is obvious synergy and complementation among universities, multinational enterprises, and mid- and small-sized enterprises. R&D organizations represented by universities denote themselves as upstream in the pharmaceutical R&D chain. As a hub, multinational enterprises play an important role as technology integrators and show the most frequent technology licensing, both in technology inflows and outflows, whereas various small firms are viewed as satellite partners around multinational enterprises. This work provides valuable insights for pharmaceutical researchers, investors, policymakers, and technology brokers not only in the field of the discovery of cardiovascular drugs but also of other therapeutic drugs. © 2015, Springer Science+Business Media New York.

KeywordCardiovascular Disease Network Pharmaceutical Industry Technology Licensing
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000370860300002
The Source to ArticleScopus
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHu Y.
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, 2053, N22, Avenida da Universidade, Taipa, Macau, 999078, China
2.Department of Pharmaceutics, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ni J.,Wan J.,Kong X.,et al. Pharmaceutical Technology Licensing: An Analysis in the Field of Cardiovascular Disease[J]. Journal of Pharmaceutical Innovation,2016,11(1):34.
APA Ni J.,Wan J.,Kong X.,Cai Y.,Yang F.,Wang Y.,&Hu Y..(2016).Pharmaceutical Technology Licensing: An Analysis in the Field of Cardiovascular Disease.Journal of Pharmaceutical Innovation,11(1),34.
MLA Ni J.,et al."Pharmaceutical Technology Licensing: An Analysis in the Field of Cardiovascular Disease".Journal of Pharmaceutical Innovation 11.1(2016):34.
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