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Panax notoginseng saponins protect against chronic ethanolinduced hepatic steatosis
Renbo Ding; Jiaolin Bao; Yiwei Cao; Chengwei He; Yitao Wang; Jianbo Wan
Source PublicationJournal of Chinese Pharmaceutical Sciences

Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease (ALD). The aim of present study is to investigate the protective effect of Panax notoginseng saponins (PNS) against chronic ethanolinduced hepatic steatosis in vivo. Mice were pairfed a modified LieberDeCarli liquid diet containing alcohol or isocaloric maltose dextrin as control diet with or without PNS (200 mg/kg, BW) for 8 weeks. Animals supplemented with PNS were protected against hepatic lipid accumulation induced by chronic ethanol exposure. Accordingly, PNS could significantly decrease the elevation of plasma triglyceride, plasma enzyme activities, i.e. alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic TNF-α and IL-6 levels which were induced by chronic alcohol exposure. In addition, PNS markedly reduced the lipolysis of white adipose tissue (WAT) that stimulated by alcohol feeding through the inhibiting protein expression of phosphorylation of hormonesensitive lipase (pHSL), rather than total HSL. Furthermore, alcohol exposure also enhanced fatty acid uptake capacity in liver by elevated hepatic CD36 expression, which could attenuated by PNS treatment. These results demonstrate that PNS supplementation protects against chronic ethanolinduced hepatic steatosis, which is associated with ameliorating dysfunctional lipid metabolism of WAT and the reduced inflammatory cytokines. Our findings suggested that PNS might be potential to be developed as an effective agent for the treatment of chronic alcoholic steatosis. © 2014 Journal of Chinese Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University.

KeywordAlcoholic Fatty Liver Inflammation Lipolysis Panax Notoginseng Saponins
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Renbo Ding,Jiaolin Bao,Yiwei Cao,et al. Panax notoginseng saponins protect against chronic ethanolinduced hepatic steatosis[J]. Journal of Chinese Pharmaceutical Sciences,2014,23(6):361.
APA Renbo Ding,Jiaolin Bao,Yiwei Cao,Chengwei He,Yitao Wang,&Jianbo Wan.(2014).Panax notoginseng saponins protect against chronic ethanolinduced hepatic steatosis.Journal of Chinese Pharmaceutical Sciences,23(6),361.
MLA Renbo Ding,et al."Panax notoginseng saponins protect against chronic ethanolinduced hepatic steatosis".Journal of Chinese Pharmaceutical Sciences 23.6(2014):361.
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