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Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells
Xiao, Yu1,2; Yang, Feng-Qing1; Li, Shao-Ping1; Gao, Jian-Li1; Hu, Guang1; Lao, Sin-Cheng1; Conceição, Emilia Leong1; Fung, Kwok-Pui3,4; Wang, Yi-Tao1,5; Lee, Simon Ming-Yuen1,4
2007-07
Source PublicationCancer Biology and Therapy
ISSN1538-4047
Volume6Issue:7Pages:1044-1050
Abstract

Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in human hepatoma HepG2 cells. Furanodiene inhibited HepG2 cell growth by causing cell cycle arrest at G(2)/M and inducing apoptosisas evidenced by DNA fragmentation assay. We found that furanodiene induced mitochondrial transmembrane depolarization, release of mitochondrial cytochrome c, activation of caspases-3 and the cleavage of PARP. The furanodiene mediated mitochondria-caspase apoptotic pathway also involved activation of p38 and inhibition of ERK mitogen-activated protein kinase (MAPK) signaling. These results for the first time have identified the biological activity of furanodiene against HepG2 cells and provide rationales for further development of essential oil of Ezhu and its ingredients such as furanodiene on treatment of liver diseases.

KeywordApoptosis Caspase-3 Cytochrome c Erk Furanodiene Hepg2 Mitochondrial P38
DOI10.4161/cbt.6.7.4317
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000250805900020
Scopus ID2-s2.0-42449136597
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Cited Times [WOS]:59   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Yi-Tao; Lee, Simon Ming-Yuen
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
2.Science and Technology Department, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, China
3.Department of Biochemistry, Chinese University of Hong Kong, Hong Kong, Hong Kong
4.Institute of Chinese Medical, Chinese University of Hong Kong, Hong Kong, Hong Kong
5.Institute of Chinese Medicine Sciences, University of Macau, Taipa, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Recommended Citation
GB/T 7714
Xiao, Yu,Yang, Feng-Qing,Li, Shao-Ping,et al. Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells[J]. Cancer Biology and Therapy,2007,6(7):1044-1050.
APA Xiao, Yu,Yang, Feng-Qing,Li, Shao-Ping,Gao, Jian-Li,Hu, Guang,Lao, Sin-Cheng,Conceição, Emilia Leong,Fung, Kwok-Pui,Wang, Yi-Tao,&Lee, Simon Ming-Yuen.(2007).Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells.Cancer Biology and Therapy,6(7),1044-1050.
MLA Xiao, Yu,et al."Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells".Cancer Biology and Therapy 6.7(2007):1044-1050.
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