UM  > Institute of Chinese Medical Sciences
TNF-alpha, a potent lipid metabolism regulator
Chen, XP; Xun, KL; Chen, LD; Wang, YT

As a multifunctional cytokine, tumor necrosis factor alpha (TNF-alpha) exerts a series of biological actions in different cells, tissues, organs, and species and has been demonstrated to regulate and interfere with energy metabolism, especially lipid homeostasis. A large body of researches suggested that the effects of TNF-alpha on lipid metabolism mainly include five aspects: ( I) Suppresses free fatty acid (FFA) uptake and promotes lipogenesis; (2) induces lipolysis; (3) inhibits lipid-metabolism-related enzymes activity, (4) regulates cholesterol metabolism; (5) regulates other adipocyte-derived adipokines. The molecular mechanisms underlying these actions are complex and several signal transduction pathways might be involved. Regulation of metabolism-related gene expression at transcriptional and protein levels and impact on enzymes activity might be of importance. Identification and verification of these pathways might provide novel potential strategies and drug targets for dyslipidemia therapy. However, the inconsistent and even conflict conclusions on lipid profile drawn from human subjects after infliximab therapy poses the possibility that the effect of TNF-alpha oil lipid metabolism might be more complicated than it appeared to be. Copyright (C) 2009 John Wiley & Sons, Ltd.

KeywordTumor Necrosis Factor Alpha Free Fatty Acid Lipolysis Cholesterol Leptin Adiponectin Infliximab
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000271078000001
Fulltext Access
Citation statistics
Cited Times [WOS]:120   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Fujian Coll Tradit Chinese Med, Fuzhou, Peoples R China
2.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China
3.Peoples Hosp Binzhou, Dept Dermatol, Binzhou, Peoples R China
Recommended Citation
GB/T 7714
Chen, XP,Xun, KL,Chen, LD,et al. TNF-alpha, a potent lipid metabolism regulator[J]. CELL BIOCHEMISTRY AND FUNCTION,2009,27(7):407-416.
APA Chen, XP,Xun, KL,Chen, LD,&Wang, YT.(2009).TNF-alpha, a potent lipid metabolism regulator.CELL BIOCHEMISTRY AND FUNCTION,27(7),407-416.
MLA Chen, XP,et al."TNF-alpha, a potent lipid metabolism regulator".CELL BIOCHEMISTRY AND FUNCTION 27.7(2009):407-416.
Files in This Item: Download All
File Name/Size Publications Version Access License
Chen_et_al-2009-Cell(231KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, XP]'s Articles
[Xun, KL]'s Articles
[Chen, LD]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, XP]'s Articles
[Xun, KL]'s Articles
[Chen, LD]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, XP]'s Articles
[Xun, KL]'s Articles
[Chen, LD]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Chen_et_al-2009-Cell_Biochemistry_and_Function.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.