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Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
Zhong, ZF (Zhong, Zhangfeng)1,2; Chen, XP (Chen, Xiuping)1; Tan, W (Tan, Wen)1; Xu, ZT (Xu, Zengtao)1; Zhou, KY (Zhou, Keyuan)2; Wu, T (Wu, Tie)2; Cui, L (Cui, Liao)2; Wang, YT (Wang, Yitao)1
2011-09-30
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
Volume667Issue:1-3Pages:50-55
Abstract

Traditional medicinal herbs are an untapped source of potential pharmaceutical compounds. This study aims to determine whether the proliferation of breast cancer cell lines could be inhibited by germacrone, a natural product isolated from Rhizoma curcuma. Germacrone treatment significantly inhibited cell proliferation, increased lactate dehydrogenase (LDH) release, and induced mitochondrial membrane potential (Delta psi m) depolarization in both MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Germacrone induced MDA-MB-231 and MCF-7 cell cycle arrest at the GO/G1 and G2/M phases respectively and induced MDA-MB-231 cell apoptosis. Furthermore, germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, BcI-xL, Bax, and Bim protein expressions. In addition, germacrone treatment induced caspase-3, 7, 9, PARP cleavage. We concluded that germacrone inhibited the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase path

KeywordPressurized-liquid-extraction D-galactosamine/lipopolysaccharide Zedoariae Rhizoma Curcuma Rhizomes Liver-injury Dna-damage Bcl-2 Sesquiterpenes Genistein Chromatography
Language英语
WOS IDWOS:000295056800009
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Cited Times [WOS]:67   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Macau, Inst Chinese Med Sci, Taipa 999078, Macau, Peoples R China
2.Guangdong Med Coll, Dept Pharmacol, Zhanjiang 524000, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhong, ZF ,Chen, XP ,Tan, W ,et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,667(1-3):50-55.
APA Zhong, ZF ,Chen, XP ,Tan, W ,Xu, ZT ,Zhou, KY ,Wu, T ,Cui, L ,&Wang, YT .(2011).Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis.EUROPEAN JOURNAL OF PHARMACOLOGY,667(1-3),50-55.
MLA Zhong, ZF ,et al."Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis".EUROPEAN JOURNAL OF PHARMACOLOGY 667.1-3(2011):50-55.
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