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Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/beta-catenin signaling
He, BC1,2,3; Gao, JL2,3; Luo, XJ1,2,3; Luo, JY1,2,3; Shen, JK1; Wang, LY1; Zhou, QX2,3; Wang, YT4; Luu, HH1; Haydon, RC1; Wang, CZ5; Du, W5,6; Yuan, CS5; He, TC1,2,3,5; Zhang, BQ1,2,3

Colorectal cancer (CRC) is one of the most common and deadly malignancies in the world. Most CRCs are initiated by aberrant activation of the Wnt/beta-catenin signaling pathway. Despite the advances in its early diagnosis, optimized surgical approaches, and chemotherapies, the clinical management ofadvanced CRC requires effective adjuvant agents. Ginsenoside Rg3 is a single compound isolated from American ginseng (Panax quinquefolius L., Araliaceae) and Asian ginseng (Panax ginseng C. A. Meyer). We investigated the anticancer activity of Rg3 on colon cancer cells and its potential molecular mechanism behind Rg3's anticancer activity. We found that Rg3 inhibits cell proliferation and viability of cancer cells in vitro. This inhibitory effect of Rg3 is, at least in part, mediated by blocking nuclear translocation of the beta-catenin protein and hence inhibiting beta-catenin/Tcf transcriptional activity. Allelic deletion ofthe oncogenic beta-catenin in HCT116 cells renders the cells more sensitive to Rg3-induced growth inhibition. Using the xenograft tumor model of human colon cancer, we have demonstrated that Rg3 effectively inhibits the growth of tumors derived from the human colon cancer cell line HCT116. Histologic examination revealed that Rg3 inhibits cancer cell proliferation, decreases PNCA expression and diminishes nuclear staining intensity of beta-catenin. Taken together, our results strongly suggest that the anticancer activity of Rg3 may be in part caused by blocking the nuclear translocation of beta-catenin in colon cancer cells. This line of investigation may lead to the development of novel therapies in which Rg3 can be used as an effective adjuvant agent for the clinical management of colorectal cancers.

KeywordColon Cancer Wnt Signaling Beta-catenin Ginsenoside Rg3 Ginseng Human Colorectal Cancer
URLView the original
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000286702600016
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Cited Times [WOS]:106   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Chicago, Med Ctr, Mol Oncol Lab, Dept Surg, Chicago, IL 60637 USA
2.Chongqing Med Univ, Dept Pharmacol, Chongqing 400016, Peoples R China
3.Chongqing Med Univ, Key Lab Diagnost Med Chinese Minist Educ, Chongqing 400016, Peoples R China
4.Univ Macau, Inst Chinese Med Sci, SAR, Macau, Peoples R China
5.Univ Chicago, Med Ctr, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA
6.Univ Chicago, Med Ctr, Ben May Dept Canc Res, Chicago, IL 60637 USA
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He, BC,Gao, JL,Luo, XJ,et al. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/beta-catenin signaling[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2011,38(2):437-445.
APA He, BC,Gao, JL,Luo, XJ,Luo, JY,Shen, JK,Wang, LY,Zhou, QX,Wang, YT,Luu, HH,Haydon, RC,Wang, CZ,Du, W,Yuan, CS,He, TC,&Zhang, BQ.(2011).Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/beta-catenin signaling.INTERNATIONAL JOURNAL OF ONCOLOGY,38(2),437-445.
MLA He, BC,et al."Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/beta-catenin signaling".INTERNATIONAL JOURNAL OF ONCOLOGY 38.2(2011):437-445.
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