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Natural products as inhibitorsof the ubiquitin-/ubiquitin-likeprotein-proteasome pathway
Ma D.-L.2; Pui-Yan Ma V.2; Shiu-Hin Chan D.2; Leung K.-H.2; Zhong H.-J.1; Leung C.-H.1
2012-10-01
AbstractThe proteasome is the final player in the regulated degradation of intracellularproteins through in both ubiquitin-dependent and ubiquitin-independent proteolyticpathways. In eukaryotic cells, the ubiquitin-proteasome system coordinates thepolyubiquitination and subsequent proteolysis of unwanted proteins, crucial to normalcellular homeostasis. The first-in-class proteasome inhibitor, bortezomib. promotesapoptosis and chemosensitization of cancer cells, and is used clinically as either a singleagentchemotherapeutic or in combination with other drugs. Natural products offermedicinal chemists with a cornucopia of diverse chemical scaffolds and bioactivesubstructures, and historically have represented an important source of new drugs.Salinosporamide A (NPI-0052), a second-generation proteasome inhibitor of marinemicrobial origin, has been effective against bortezomib-resistant cancers and has enteredPhase I clinical trials. This review discusses the application of natural products asinhibitors of the ubiquitin-proteasome system through targeting of both conventional proteolytic pathways as well as those involving ubiquitin-like proteins, such as NEDD8,which have recently emerged as novel anti-cancer targets. © 2012 by Nova Science Publishers, Inc. All rights reserved.
ISBN9781620817285;
URLView the original
Pages55-74
Language英語English
Fulltext Access
Document TypeBook
CollectionUniversity of Macau
Affiliation1.University of Macau
2.Hong Kong Baptist University
Recommended Citation
GB/T 7714
Ma D.-L.,Pui-Yan Ma V.,Shiu-Hin Chan D.,et al. Natural products as inhibitorsof the ubiquitin-/ubiquitin-likeprotein-proteasome pathway[M],2012.
APA Ma D.-L.,Pui-Yan Ma V.,Shiu-Hin Chan D.,Leung K.-H.,Zhong H.-J.,&Leung C.-H..(2012).Natural products as inhibitorsof the ubiquitin-/ubiquitin-likeprotein-proteasome pathway. .
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