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Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone
Sun, Kai1; Yang, Yingkun1; Zhou, Hua1; Yin, Shengyan1; Qin, Weiping1; Yu, Jiangbo3; Chiu, Daniel T.3; Yuan, Zhen4; Zhang, Xuanjun4; Wu, Changfeng2
Source PublicationACS NANO

Optical methods such as absorptiometry, fluorescence, and surface plasmon resonance have long been explored for sensing glucose. However, these schemes have not had the clinical success of electrochemical methods for point-of-care testing because of the limited performance of optical sensors and the bulky instruments they require. Here, we show that an ultrasensitive optical transducer can be used for wireless glucose monitoring via a smartphone. The optical transducer combines oxygen sensitive polymer dots (Pdots) with glucose oxidase that sensitively detect glucose when oxygen is consumed in the glucose oxidation reaction. By judicious design of the Pdots with ultralong phosphorescence lifetime, the transducer exhibited a significantly enhanced sensitivity by 1 order of magnitude as compared to the one in a previous study. As a result, the optical images of subcutaneous glucose level obtained with the smartphone camera could be utilized to clearly distinguish between euglycemia and hyperglycemia. We further developed an image processing algorithm and a software application that was installed on a smartphone. Real-time dynamic glucose monitoring in live mice was demonstrated with the smartphone and the implanted Pdot transducer.

KeywordDiabetes Continuous Glucose Monitoring Semiconducting Polymer Dots Fluorescence Imaging Smartphone
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000436910200012
The Source to ArticleWOS
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Cited Times [WOS]:68   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, China
2.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
3.Department of Chemistry and Bioengineering, University of Washington, Seattle, Washington 98195, United States
4.Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, China
Recommended Citation
GB/T 7714
Sun, Kai,Yang, Yingkun,Zhou, Hua,et al. Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone[J]. ACS NANO,2018,12(6):5176-5184.
APA Sun, Kai,Yang, Yingkun,Zhou, Hua,Yin, Shengyan,Qin, Weiping,Yu, Jiangbo,Chiu, Daniel T.,Yuan, Zhen,Zhang, Xuanjun,&Wu, Changfeng.(2018).Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone.ACS NANO,12(6),5176-5184.
MLA Sun, Kai,et al."Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone".ACS NANO 12.6(2018):5176-5184.
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