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Recent advances in breast cancer metastasis suppressor 1
Chen XP; Xu ZT; Wang YT
Source PublicationInternational Journal of Biological Markers

Metastasis is a complex process divided into a number of steps including detachment of tumor cells from the primary tumor, invasion, migration, intravasation, survival in the vasculature, extravasation, and colonization of the secondary site. Proteins that block metastasis without inhibiting primary tumor formation are known as metastasis suppressors; examples are NM23, Maspin, KAI1, KISS1, and MKK4. Breast cancer metastasis suppressor 1 (BRMS1) was identified as a suppressor of breast cancer metastasis in the late 1990s. In vitro and in vivo studies have confirmed that BRMS1 is a potent metastasis suppressor not limited to breast cancer. However, conflicting clinical observations regarding its role as a metastasis suppressor and its validity as a diagnostic biomarker warrant more in-depth clinical study. In this review, the authors provide an overview of its biology, function, action mechanism and pathological significance.

KeywordBrms1 Gap Junctional Intercellular Communication Msin3-hdac Microrna Nf-kb
Indexed BySCIE
WOS Research AreaBiotechnology & Applied Microbiology ; Oncology
WOS SubjectBiotechnology & Applied Microbiology ; Oncology
WOS IDWOS:000290909500001
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationInstitute of Chinese Medical Sciences, University of Macau, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen XP,Xu ZT,Wang YT. Recent advances in breast cancer metastasis suppressor 1[J]. International Journal of Biological Markers,2011,26(1):1-8.
APA Chen XP,Xu ZT,&Wang YT.(2011).Recent advances in breast cancer metastasis suppressor 1.International Journal of Biological Markers,26(1),1-8.
MLA Chen XP,et al."Recent advances in breast cancer metastasis suppressor 1".International Journal of Biological Markers 26.1(2011):1-8.
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