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Bioactive iridium and rhodium complexes as therapeutic agents
Leung CH1; Zhong HJ1; Chan DSH2; Ma DL2
2013
Source PublicationCoord Chem Rev
ISSN0010-8545
Volume257Issue:11-12Pages:1764-1776
Abstract

Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded as chemically inert, studies over the past few years have demonstrated that the reactivity and biological activity of iridium and rhodium complexes may be unlocked by a suitable choice of auxiliary ligands. In addition, group 9 metal centers have received increased popularity for the construction of kinetically inert organometallic scaffolds as target-selective protein or enzyme inhibitors. In this review, we summarize the recent strategies that have been utilized for the design and development of bioactive iridium and rhodium complexes.

KeywordIridium Metallodrug Inorganic Medicine Rhodium Anti-cancer
DOIhttps://doi.org/10.1016/j.ccr.2013.01.034
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000318131700004
Scopus ID2-s2.0-84874643375
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Cited Times [WOS]:235   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Leung CH,Zhong HJ,Chan DSH,et al. Bioactive iridium and rhodium complexes as therapeutic agents[J]. Coord Chem Rev,2013,257(11-12):1764-1776.
APA Leung CH,Zhong HJ,Chan DSH,&Ma DL.(2013).Bioactive iridium and rhodium complexes as therapeutic agents.Coord Chem Rev,257(11-12),1764-1776.
MLA Leung CH,et al."Bioactive iridium and rhodium complexes as therapeutic agents".Coord Chem Rev 257.11-12(2013):1764-1776.
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