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Roles of the activin regulatory system in fish reproduction
Ge W.
Source PublicationCanadian Journal of Physiology and Pharmacology
AbstractActivin (βAβA, βAβB, and βBβB) is a dimeric growth factor with diverse biological activities in vertebrate reproduction. Activin exerts its actions by binding to its specific type II and type I receptors. The activity of activin is regulated by follistatin, its binding protein, and the antagonists inhibin and antivin. All major components of the activin-inhibin-follistatin system have been identified in fish except the α subunit of inhibin. Using goldfish as a model, we have demonstrated that activin is expressed in the pituitary and the recombinant goldfish activin B has novel inverse effects on the expression of GTH β subunits. Activin increases the mRNA level of GTH-Iβ while significantly suppressing the expression of GTH-IIβ. We have also demonstrated the expression of activin and its receptors in the goldfish and zebrafish ovary. Using an in vitro ovarian follicle incubation as the system, we have investigated the involvement of the activin system in the process of final oocyte maturation. Our evidence clearly indicates that activin has potent effect of promoting final oocyte maturation, and that it may play a role in mediating the stimulatory effect of pituitary gonadotropin in the event of oocyte maturation.
KeywordActivin Fish Follistatin Inhibin Reproduction
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Document TypeConference paper
CollectionFaculty of Health Sciences
AffiliationDepartment of Biology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
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GB/T 7714
Ge W.. Roles of the activin regulatory system in fish reproduction[C],2000:1077.
APA Ge W..(2000).Roles of the activin regulatory system in fish reproduction.Canadian Journal of Physiology and Pharmacology,78(12),1077.
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