Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control | |
Deng C.2![]() | |
1995-08-25 | |
Source Publication | Cell
![]() |
ISSN | 00928674 |
Volume | 82Issue:4Pages:675-684 |
Abstract | p21 is a CDK Inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21. They develop normally and (unlike p53 mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21 embryonic fibroblasts are significantly deficient in their ability to arrest in G1 In response to DNA damage and nucleotide pool perturbation. p21 cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed In p53-/- cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21 in the G1 checkpoint, but suggest that the antiapoptotic and the anti-oncogenic effects of p53 are more complex. © 1995. |
DOI | 10.1016/0092-8674(95)90039-X |
URL | View the original |
Indexed By | SCI |
Language | 英语 |
WOS Research Area | Biochemistry & Molecular Biology ; Cell Biology |
WOS Subject | Biochemistry & Molecular Biology ; Cell Biology |
WOS ID | WOS:A1995RR73400018 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Personal research not belonging to the institution |
Affiliation | 1.Baylor College of Medicine 2.Harvard Medical School |
Recommended Citation GB/T 7714 | Deng C.,Zhang P.,Wade Harper J.,et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control[J]. Cell,1995,82(4):675-684. |
APA | Deng C.,Zhang P.,Wade Harper J.,Elledge S.J.,&Leder P..(1995).Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.Cell,82(4),675-684. |
MLA | Deng C.,et al."Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control".Cell 82.4(1995):675-684. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment