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Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics
Zhou L.2; Jing Y.2; Liu Y.4; Liu Z.2; Gao D.4; Chen H.2; Song W.2; Wang T.2; Fang X.2; Qin W.2; Yuan Z.4; Dai S.1; Qiao Z.-A.2; Wu C.3
Source PublicationTheranostics

Optical nanomaterials with intense absorption in near-infrared (NIR) region hold great promise for biomedical applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). In this work, we report mesoporous carbon nanospheres (Meso-CNs) with broadband and intense absorption in the UV-Vis-NIR region (300-1400 nm) and explore their potential as a multifunctional platform for photoacoustic imaging and chemo-photothermal therapy. Methods: Meso-CNs were prepared by a "silica-assisted" synthesis strategy and characterized by transmission electron microscope and optical spectroscopy. We investigated the photothermal conversion and photoacoustic imaging of Meso-CNs in comparison with single-walled carbon nanotubes (SWCNTs), graphene and gold nanorods (GNRs). In vitro cellular assays and in vivo chemo-photothermal combination therapy were performed. Results: The absorption coefficients of Meso-CNs are 1.5-2 times higher than those of SWCNTs and graphene and are comparable to those of GNRs in both the first and the second near-infrared optical windows (NIR-I and NIR-II) of tissues. When exposed to an NIR laser, the photothermal and photoacoustic signal generation of Meso-CNs are also stronger than those of SWCNTs, graphene, and GNRs. DOX was loaded into Meso-CNs with a high efficiency (35 wt%) owing to the unique mesoporous structure. Particularly, the drug release from Meso-CNs is sensitive to both pH and NIR light stimulation. In vivo chemo-photothermal combination therapy demonstrates a remarkable inhibition effect on tumor growth under NIR laser treatment. Conclusions: We have developed Meso-CNs for photothermal conversion and photoacoustic imaging. The porous structure also serves as a drug carrier and the drug release can be controlled by pH and external light. The high drug loading capacity, superior photothermal and photoacoustic generation, together with the apparent chemo-photothermal therapeutic effect, make Meso-CNs a promising platform for cancer theranostics.

KeywordDrug Delivery Mesoporous Carbon Nanospheres Near-infrared Absorption Photoacoustic Imaging Photothermal Therapy
URLView the original
Indexed BySCIE
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000417132600006
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Cited Times [WOS]:79   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Oak Ridge National Laboratory
2.Jilin University
3.Southern University of Science and Technology
4.Universidade de Macau
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GB/T 7714
Zhou L.,Jing Y.,Liu Y.,et al. Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics[J]. Theranostics,2018,8(3):663-675.
APA Zhou L.,Jing Y.,Liu Y.,Liu Z.,Gao D.,Chen H.,Song W.,Wang T.,Fang X.,Qin W.,Yuan Z.,Dai S.,Qiao Z.-A.,&Wu C..(2018).Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics.Theranostics,8(3),663-675.
MLA Zhou L.,et al."Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics".Theranostics 8.3(2018):663-675.
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