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Integration of genomic data for pharmacology and toxicology using Internet resources
Paananen J.; Wong G.
Source PublicationSAR and QSAR in Environmental Research
ISSN1062936X 1029046X
AbstractGenome based technologies such as sequencing and gene expression profiling using microarrays are creating massive amounts of data. Results from these studies have provided unique insights into targets, biochemical pathways, and biological systems affected by drug or xenobiotic chemical treatments. Moreover, these genomic technologies offer the potential to identify biomarkers for pharmacological development or toxicological prediction. Nonetheless, microarray studies involving a single compound produce useful although limited data. To gain further power from these individual studies, the ability to combine datasets through integration schemes has become imperative. In the current study, we describe and analyze currently available Internet resources designed to address this problem. Many functionalities, such as ability to cross reference orthologous genes across species or to combine same technology platform data, are present in these resources. Nonetheless, these resources are limited in the number of technology platforms they can support. While the ability to integrate all currently existing gene expression datasets remains enigmatic, the current tools provide a partial solution that may still yield unique insights into the affects of exogenous molecules at the level of gene expression. © 2006 Taylor & Francis.
KeywordBioinformatics Genomic data Integration Internet
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationItä-Suomen yliopisto
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GB/T 7714
Paananen J.,Wong G.. Integration of genomic data for pharmacology and toxicology using Internet resources[J]. SAR and QSAR in Environmental Research,2006,17(1):25-36.
APA Paananen J.,&Wong G..(2006).Integration of genomic data for pharmacology and toxicology using Internet resources.SAR and QSAR in Environmental Research,17(1),25-36.
MLA Paananen J.,et al."Integration of genomic data for pharmacology and toxicology using Internet resources".SAR and QSAR in Environmental Research 17.1(2006):25-36.
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