| Affiliated with RC | false |
| Status | 已發表Published |
| Reproductive role of miRNA in the hypothalamic-pituitary axis | |
| Cao, Chunyu; Ding, Yifei; Kong, Xiangjun; Feng, Guangde; Xiang, Wei; Chen, Long; Yang, Fang; Zhang, Ke; Chu, Mingxing; Wang, Pingqing; Zhang, Baoyun | |
| 2018-04 | |
| Source Publication | MOLECULAR AND CELLULAR NEUROSCIENCE
 |
| ISSN | 1044-7431 |
| Volume | 88Pages:130-137 |
| Abstract | The hypothalamic-pituitary-gonz dal (HPG) axis plays a critical role in regulating reproductive function. Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonado-trophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion, ultimately affecting the animal's fertility. MicroRNAs are small, non-coding RNAs that are widely expressed throughout the brain and can fins-tune gene expression post-transcriptionally. Recently, growing evidence has unveiled the central position of miRNAs within a key regulatory process involving GnRH secretion and subsequent activation in the pituitary. Although transcriptional regulation of reproduction has been well studied, the post-transcriptional processes are less well understood. In this review, we elaborate comprehensively on the critical role of miRNAs in the reproductive process, including both temporal and spatial aspects. A better understanding of how miRNAs impart the neuroendocrine system may improve our knowledge of reproduction and provide novel targets for therapeutic development. |
| Keyword | MiRNA Hypothalamus-pituitary axis GnRH neuron Reproduction |
| DOI | 10.1016/j.mcn.2018.01.008 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Neurosciences |
| WOS ID | WOS:000431097300013 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| The Source to Article | WOS |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Recommended Citation GB/T 7714 | Cao, Chunyu,Ding, Yifei,Kong, Xiangjun,et al. Reproductive role of miRNA in the hypothalamic-pituitary axis[J]. MOLECULAR AND CELLULAR NEUROSCIENCE,2018,88:130-137. |
| APA | Cao, Chunyu,Ding, Yifei,Kong, Xiangjun,Feng, Guangde,Xiang, Wei,Chen, Long,Yang, Fang,Zhang, Ke,Chu, Mingxing,Wang, Pingqing,&Zhang, Baoyun.(2018).Reproductive role of miRNA in the hypothalamic-pituitary axis.MOLECULAR AND CELLULAR NEUROSCIENCE,88,130-137. |
| MLA | Cao, Chunyu,et al."Reproductive role of miRNA in the hypothalamic-pituitary axis".MOLECULAR AND CELLULAR NEUROSCIENCE 88(2018):130-137. |
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