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Reproductive role of miRNA in the hypothalamic-pituitary axis
Cao, Chunyu; Ding, Yifei; Kong, Xiangjun; Feng, Guangde; Xiang, Wei; Chen, Long; Yang, Fang; Zhang, Ke; Chu, Mingxing; Wang, Pingqing; Zhang, Baoyun
AbstractThe hypothalamic-pituitary-gonz dal (HPG) axis plays a critical role in regulating reproductive function. Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonado-trophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion, ultimately affecting the animal's fertility. MicroRNAs are small, non-coding RNAs that are widely expressed throughout the brain and can fins-tune gene expression post-transcriptionally. Recently, growing evidence has unveiled the central position of miRNAs within a key regulatory process involving GnRH secretion and subsequent activation in the pituitary. Although transcriptional regulation of reproduction has been well studied, the post-transcriptional processes are less well understood. In this review, we elaborate comprehensively on the critical role of miRNAs in the reproductive process, including both temporal and spatial aspects. A better understanding of how miRNAs impart the neuroendocrine system may improve our knowledge of reproduction and provide novel targets for therapeutic development.
KeywordMiRNA Hypothalamus-pituitary axis GnRH neuron Reproduction
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Indexed BySCIE
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000431097300013
The Source to ArticleWOS
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Cao, Chunyu,Ding, Yifei,Kong, Xiangjun,et al. Reproductive role of miRNA in the hypothalamic-pituitary axis[J]. MOLECULAR AND CELLULAR NEUROSCIENCE,2018,88:130-137.
APA Cao, Chunyu,Ding, Yifei,Kong, Xiangjun,Feng, Guangde,Xiang, Wei,Chen, Long,Yang, Fang,Zhang, Ke,Chu, Mingxing,Wang, Pingqing,&Zhang, Baoyun.(2018).Reproductive role of miRNA in the hypothalamic-pituitary axis.MOLECULAR AND CELLULAR NEUROSCIENCE,88,130-137.
MLA Cao, Chunyu,et al."Reproductive role of miRNA in the hypothalamic-pituitary axis".MOLECULAR AND CELLULAR NEUROSCIENCE 88(2018):130-137.
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