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MnSOD mediates shear stress-promoted tumor cell migration and adhesion
Shijun Ma1; Afu Fu1; Sierin Lim1; Geraldine Giap Ying Chiew1; Kathy Qian Lu2
Source PublicationFree Radical Biology and Medicine

Circulation of cancer cells in the bloodstream is a vital step for distant metastasis, during which cancer cells are exposed to hemodynamic shear stress (SS). The actions of SS on tumor cells are complicated and not fully understood. We previously reported that fluidic SS was able to promote migration of breast cancer cells by elevating the cellular ROS level. In this study, we further investigated the mechanisms regulating SS-promoted cell migration and identified the role of MnSOD in the related pathway. We found that SS could enhance tumor cell adhesion to extracellular matrix and endothelial monolayer, and MnSOD also regulated this process. Briefly, SS stimulates the generation of mitochondrial superoxide in tumor cells. MnSOD then converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion. Combining our previous and present studies, we present experimental evidence on the prometastatic effects of hemodynamic SS and reveal the underlying mechanism. Our findings provide new insights into the nature of cancer metastasis and the understanding of tumor cell responses to external stresses and have valuable implications for cancer therapy development.

KeywordShear Stress Tumor Cell Adhesion Tumor Cell Migration Reactive Oxygen Species Mnsod Fak
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000450298400004
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
2.Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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GB/T 7714
Shijun Ma,Afu Fu,Sierin Lim,et al. MnSOD mediates shear stress-promoted tumor cell migration and adhesion[J]. Free Radical Biology and Medicine,2018,129:46-58.
APA Shijun Ma,Afu Fu,Sierin Lim,Geraldine Giap Ying Chiew,&Kathy Qian Lu.(2018).MnSOD mediates shear stress-promoted tumor cell migration and adhesion.Free Radical Biology and Medicine,129,46-58.
MLA Shijun Ma,et al."MnSOD mediates shear stress-promoted tumor cell migration and adhesion".Free Radical Biology and Medicine 129(2018):46-58.
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