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The dual lives of bidirectional promoters
Clay Wakano; Jung S.Byun; Li-JunDi; Kevin Gardner
Source PublicationBiochimica et Biophysica Acta

The sequencing of the human genome led to many insights into gene organization and structure. One interesting observation was the high frequency of bidirectional promoters characterized by two protein encoding genes whose promoters are arranged in a divergent or “head-to-head” configuration with less than 2000 base pairs of intervening sequence. Computational estimates published by various groups indicate that nearly 10% of the coding gene promoters are arranged in such a manner and the extent of this bias is a unique feature of mammalian genomes. Moreover, as a class, head-to-head promoters appear to be enriched in specific categories of gene function. Here we review the structure, composition, genomic properties and functional classifications of genes controlled by bidirectional promoters and explore the biological implication of these features. This article is part of a Special Issue entitled: Chromatin in time and space.

KeywordPromoter Transcription Chromatin Gene Regulation
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000306265100010
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Cited Times [WOS]:39   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationGenetics Branch, National Cancer Institute, Bethesda, MD 20892, USA Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, USA
Recommended Citation
GB/T 7714
Clay Wakano,Jung S.Byun,Li-JunDi,et al. The dual lives of bidirectional promoters[J]. Biochimica et Biophysica Acta,2012,1819(2012):688–693.
APA Clay Wakano,Jung S.Byun,Li-JunDi,&Kevin Gardner.(2012).The dual lives of bidirectional promoters.Biochimica et Biophysica Acta,1819(2012),688–693.
MLA Clay Wakano,et al."The dual lives of bidirectional promoters".Biochimica et Biophysica Acta 1819.2012(2012):688–693.
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