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Screening Neuroprotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review
Xiuping Chen; Jiajie Guo; Jiaolin Bao; Wenshan Xu; Yanjuan Huang; Yitao Wang
2012
Source PublicationCurrent Psychopharmacology
ISSN2211-5560
Volume1Issue:1Pages:103 - 110
Abstract

The epidemic of neurodegenerative diseases, such as Alzheimer's disease, Parkinson’s disease, and cerebral ischemia (e.g., stroke), has long been a worldwide health and social concern with the rapid increase of aging population. To date, efficient therapeutic drugs are still insufficient, making the treatment of these diseases a big challenge to both basic researchers and clinical physicians. A few in vitro and in vivo experimental models are established to explore, as well as evaluate, protective and therapeutic agents. Among these models, cell-based screening models play an important role in the initial step of searching and identifying neuroprotective compounds. Primary cultured hippocampal and cortical neurons, as well as PC12 and SH-SY5Y cells, are among the frequently applied cells in these models. PC12 is an immortalized pheochromocytoma cell line that provides a series of classical screening models by applying a variety of neurotoxins, such as 6-hydroxydopamine, beta amyloid, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and paraquat, among others. In the present review, several neuroprotective and injury models induced by 4-hydroxynonenal, ethanol, high glucose, homocysteine, okadaic acid, rotenone, and oxygen-glucose deprivation, as well as documented protective agents, are discussed.

KeywordNeuroprotective Agent Screening Model Pc12 Oxidative Stress
DOIhttp://dx.doi.org/10.2174/2211556011201010103
Language英語English
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiuping Chen
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiuping Chen,Jiajie Guo,Jiaolin Bao,et al. Screening Neuroprotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review[J]. Current Psychopharmacology,2012,1(1):103 - 110.
APA Xiuping Chen,Jiajie Guo,Jiaolin Bao,Wenshan Xu,Yanjuan Huang,&Yitao Wang.(2012).Screening Neuroprotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review.Current Psychopharmacology,1(1),103 - 110.
MLA Xiuping Chen,et al."Screening Neuroprotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review".Current Psychopharmacology 1.1(2012):103 - 110.
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