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Antipsychotic polypharmacy in inpatients with schizophrenia in Asia
Xiang, YT1,2; Wang, CY2; Si, TM3; Lee, EHM1; He, YL4; Ungvari, GS5; Chiu, HFK1; Yang, SY6; Chong, MY7,8; Tan, CH9; Kua, EH9; Fujii, S10; Sim, K11; Yong, KH11; Trivedi, JK12; Chung, EK13; Udomratn, P14; Chee, KY15; Sartorius, N16; Shinfuku, N17

Objective: This study aimed to identify trends in the use of antipsychotic polypharmacy (APP) and their demographic and clinical correlates in the treatment of schizophrenia in Asia between 2001 and 2009. 

Method: A total of 6761 schizophrenia inpatients in 9 Asian countries and territories were examined; 2399 in 2001, 2136 in 2004, and 2226 in 2009. Patients' socio-demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. 

Results: The proportion of APP prescription decreased from 46.8% in 2001, to 38.3% in 2004, and increased to 43.4% in 2009, with wide inter-country variations at each survey. Multiple logistic regression analysis of the whole sample revealed that patients on APP were younger, had a higher dose of antipsychotics in chlorpromazine equivalents, and more severe positive and negative symptoms. They were also more likely to receive depot and first-generation antipsychotic drugs. 

Conclusions: The frequency of APP prescription varied between countries and territories, suggesting that a host of clinical and socio-cultural factors played a role in determining APP use in Asia. To resolve the discrepancy between treatment recommendation and clinical practice, regular reviews of prescription patterns are needed.

KeywordSchizophrenia Antipsychotic Polypharmacy Prescription Patterns
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy ; Psychiatry
WOS SubjectPharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000299909600002
Fulltext Access
Citation statistics
Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
5.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australi
6.Taipei City Hosp, Taipei, Taiwan
7.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Guishan, Taiwan
8.Chang Gung Univ, Sch Med, Guishan, Taiwan
9.Natl Univ Singapore, Singapore 117548, Singapore
10.HITS, Kobe, Hyogo, Japan
11.Inst Mental Hlth, Singapore, Singapore
12.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
13.Natl Seoul Hosp, Seoul, South Korea
14.Prince Songkla Univ, Dept Psychiat, Fac Med, Hat Yai, Thailand
15.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
16.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
17.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
Recommended Citation
GB/T 7714
Xiang, YT,Wang, CY,Si, TM,et al. Antipsychotic polypharmacy in inpatients with schizophrenia in Asia[J]. PHARMACOPSYCHIATRY,2012,45(1):7-12.
APA Xiang, YT,Wang, CY,Si, TM,Lee, EHM,He, YL,Ungvari, GS,Chiu, HFK,Yang, SY,Chong, MY,Tan, CH,Kua, EH,Fujii, S,Sim, K,Yong, KH,Trivedi, JK,Chung, EK,Udomratn, P,Chee, KY,Sartorius, N,&Shinfuku, N.(2012).Antipsychotic polypharmacy in inpatients with schizophrenia in Asia.PHARMACOPSYCHIATRY,45(1),7-12.
MLA Xiang, YT,et al."Antipsychotic polypharmacy in inpatients with schizophrenia in Asia".PHARMACOPSYCHIATRY 45.1(2012):7-12.
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