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Common use of antipsychotic polypharmacy in older Asian patients with schizophrenia (2001
Xiang, YT1,2,3; Dickerson, F4; Kreyenbuhl, J5; Ungvari, GS6; Wang, CY2; Si, TM7,8; Lee, EHM1; He, YL9; Chiu, HFK1; Yang, SY10; Chong, MY11,12; Tan, CH13; Kua, EH13; Fujii, S14; Sim, K15; Yong, MKH15; Trivedi, JK15; Chung, EK16; Udomratn, P17; Chee, KY18; Sartorius, N19,20; Shinfuku, N20

Objective: The aim of this study was to survey the use of antipsychotic polypharmacy (APP) in older Asian patients with schizophrenia and examine its demographic and clinical correlates. 

Methods: Information on hospitalized patients with schizophrenia aged 55 or older was extracted from the database of the Research on Asian Psychotropic Prescription Patterns study. Data on 1439 patients in 6 Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, and Taiwan were analyzed. Sociodemographic and clinical characteristics and antipsychoticprescriptions were recorded using a standardized protocol and data collection procedure. 

Results: The frequency of APP prescription was 51.6% in the pooled sample with wide intercountry variations. Multiple logistic regression analysis of the whole sample showed that patients on APP had higher antipsychotic doses and also were more likely to receive first-generation antipsychotics. 

Conclusions: Use of APP was common in older Asian patients with schizophrenia. Given the limited evidence supporting its efficacy, the potentially severe side effects and high costs, APP should be used with caution in this population. The reasons for and outcomes of the use of APP in this patient population merit further exploration.

KeywordSchizophrenia Prescription Patterns Antipsychotic Polypharmacy Psychogeriatric Patients Asia
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy ; Psychiatry
WOS SubjectPharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000310923500013
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Citation statistics
Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
3.Univ Maryland, Sch Med, Dept Psychiat, Div Res Serv, Baltimore, MD 21201 USA
4.Stanley Res Program Sheppard Pratt, Stanley, Hong Kong, Peoples R China
5.Mental Illness Res Educ & Clin Ctr, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
6.Univ Notre Dame, Marian Ctr, Perth, WA, Australia
7.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
8.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Taipei City Hosp, Taipei, Taiwan
11.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
12.Chang Gung Univ, Sch Med, Kaohsiung, Taiwan
13.Natl Univ Singapore, Singapore 117548, Singapore
14.Hyogo Inst Traumat Stress, Kobe, Hyogo, Japan
15.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
16.Natl Seoul Hosp, Seoul, South Korea
17.Prince Songkla Univ, Hat Yai, Thailand
18.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
19.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
20.Seinan Gakuin Univ Fukuoka, Fukuoka, Japan
Recommended Citation
GB/T 7714
Xiang, YT,Dickerson, F,Kreyenbuhl, J,et al. Common use of antipsychotic polypharmacy in older Asian patients with schizophrenia (2001[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2012,32(6):809-813.
APA Xiang, YT.,Dickerson, F.,Kreyenbuhl, J.,Ungvari, GS.,Wang, CY.,Si, TM.,Lee, EHM.,He, YL.,Chiu, HFK.,Yang, SY.,Chong, MY.,Tan, CH.,Kua, EH.,Fujii, S.,Sim, K.,Yong, MKH.,Trivedi, JK.,Chung, EK.,Udomratn, P.,...&Shinfuku, N.(2012).Common use of antipsychotic polypharmacy in older Asian patients with schizophrenia (2001.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,32(6),809-813.
MLA Xiang, YT,et al."Common use of antipsychotic polypharmacy in older Asian patients with schizophrenia (2001".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 32.6(2012):809-813.
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