Affiliated with RCfalse
QTc prolongation in schizophrenia patients in Asia: Clinical Correlates and Trends between 2004 and 2008/2009
Xiang, YT1,2; Chiu, HFK2; Ungvari, GS3; Correll, CU4; Lai, KYC2; Wang, CY5; Si, TM6,7; Lee, EHM8; He, YL9; Yang, SY10; Chong, MY11,12; Kua, EH13; Fujii, S14; Sim, K15; Yong, MKH15; Trivedi, JK16; Chung, EK17; Udomratn, P18; Chee, KY19; Sartorius, N20; Tan, CH21; Shinfuku, N22

ObjectiveLittle is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. 

MethodData on 3482 hospitalized schizophrenia patients (2004=1826 and 2008/2009=1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. 

ResultsThe frequency of QTc prolongation (>456ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p=0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values<0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTcprolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5). 

ConclusionsFrequency of QTc prolongation was low in Asian patients with schizophrenia. QTcprolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries. Copyright (c) 2015 John Wiley & Sons, Ltd.

KeywordSchizophrenia Asia Inpatients Qtc Prolongation
Indexed BySCIE
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000351400900004
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
2.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
3.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
4.Zucker Hillside Hosp, Div Psychiat Res, North Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY USA
5.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
6.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
7.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
8.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Taipei City Hosp, Taipei, Taiwan
11.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Gueishan, Taiwan
12.Chang Gung Univ, Sch Med, Gueishan, Taiwan
13.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
14.Fukushima Med Univ, Fukushima, Japan
15.Inst Mental Hlth, Buangkok, Singapore
16.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
17.Natl Seoul Hosp, Dept Psychiat, Seoul, South Korea
18.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
19.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
20.Associat Improvement Mental Hlth Programs, Geneva, Switzerland
21.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore
22.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Xiang, YT,Chiu, HFK,Ungvari, GS,et al. QTc prolongation in schizophrenia patients in Asia: Clinical Correlates and Trends between 2004 and 2008/2009[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2015,30(2):94-99.
APA Xiang, YT.,Chiu, HFK.,Ungvari, GS.,Correll, CU.,Lai, KYC.,Wang, CY.,Si, TM.,Lee, EHM.,He, YL.,Yang, SY.,Chong, MY.,Kua, EH.,Fujii, S.,Sim, K.,Yong, MKH.,Trivedi, JK.,Chung, EK.,Udomratn, P.,Chee, KY.,...&Shinfuku, N.(2015).QTc prolongation in schizophrenia patients in Asia: Clinical Correlates and Trends between 2004 and 2008/2009.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,30(2),94-99.
MLA Xiang, YT,et al."QTc prolongation in schizophrenia patients in Asia: Clinical Correlates and Trends between 2004 and 2008/2009".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 30.2(2015):94-99.
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