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A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy
Yang, Guan Jun1,2,4,5; Wu, Jia2; Leung, Chung Hang2,6; Ma, Dik Lung3; Chen, Jiong1,2,4
2021-12-15
Source PublicationInternational Journal of Biological Macromolecules
ISSN0141-8130
Volume193Pages:1499-1506
Abstract

Glycolysis is an important step in respiration and provides energy for cellular processes. Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, plays an important role in tumor cell metabolism and proliferation. It is also specifically overexpressed in leukemia cells and contributes to leukemic proliferation, differentiation, and drug resistance through both aerobic glycolysis and non-metabolic pathways. In this review, the functions and regulatory roles of PKM2 are firstly introduced. Then, the molecular mechanisms of PKM2 in leukemogenesis are summarized. Next, reported PKM2 modulators and their anti-leukemia mechanisms are described. Finally, the current challenges and the potential opportunities of PKM2 inhibitors or agonists in leukemia therapy are discussed.

KeywordLeukemia Modulators Pyruvate Kinase M2
DOI10.1016/j.ijbiomac.2021.10.213
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000734378600011
Scopus ID2-s2.0-85118870639
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen, Jiong
Affiliation1.State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, China
2.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China
3.Department of Chemistry, Hong Kong Baptist University, Kowloon, 999077, Hong Kong
4.Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo, 315211, China
5.Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo, 315211, China
6.Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macao SAR, 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang, Guan Jun,Wu, Jia,Leung, Chung Hang,et al. A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy[J]. International Journal of Biological Macromolecules,2021,193:1499-1506.
APA Yang, Guan Jun,Wu, Jia,Leung, Chung Hang,Ma, Dik Lung,&Chen, Jiong.(2021).A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy.International Journal of Biological Macromolecules,193,1499-1506.
MLA Yang, Guan Jun,et al."A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy".International Journal of Biological Macromolecules 193(2021):1499-1506.
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