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Ghrelin receptor regulates adipose tissue inflammation in aging
Lin L.1; Lee J.H.1; Buras E.D.3; Yu K.2; Wang R.2; Wayne Smith C.1; Wu H.1; Sheikh-Hamad D.1; Sun Y.1
Source PublicationAging

Aging is commonly associated with low-grade adipose inflammation, which is closely linked to insulin resistance. Ghrelin is the only circulating orexigenic hormone which is known to increase obesity and insulin resistance. We previously reported that the expression of the ghrelin receptor, growth hormone secretagogue receptor (GHS-R), increases in adipose tissues during aging, and old Ghsr mice exhibit a lean and insulin-sensitive phenotype. Macrophages are major mediators of adipose tissue inflammation, which consist of pro-inflammatory M1 and anti-inflammatory M2 subtypes. Here, we show that in aged mice, GHS-R ablation promotes macrophage phenotypical shift toward antiinflammatory M2. Old Ghsr mice have reduced macrophage infiltration, M1/M2 ratio, and pro-inflammatory cytokine expression in white and brown adipose tissues. We also found that peritoneal macrophages of old Ghsr mice produce higher norepinephrine, which is in line with increased alternatively-activated M2 macrophages. Our data further reveal that GHS-R has cell-autonomous effects in macrophages, and GHS-R antagonist suppresses lipopolysaccharide (LPS)- induced inflammatory responses in macrophages. Collectively, our studies demonstrate that ghrelin signaling has an important role in macrophage polarization and adipose tissue inflammation during aging. GHS-R antagonists may serve as a novel and effective therapeutic option for age-associated adipose tissue inflammation and insulin resistance.

KeywordAdipose Tissue Macrophages (Atms) Ghrelin Growth Hormone Secretagogue Receptor (Ghs-r) Inflammation Peritoneal Macrophages (Pm) Thermogenesis
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Indexed BySCIE
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000372085500014
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Baylor College of Medicine
2.Harbin Medical University
3.University of Michigan Medical School
4.Texas A and M University
5.Universidade de Macau
Recommended Citation
GB/T 7714
Lin L.,Lee J.H.,Buras E.D.,et al. Ghrelin receptor regulates adipose tissue inflammation in aging[J]. Aging,2016,8(1):178-191.
APA Lin L.,Lee J.H.,Buras E.D.,Yu K.,Wang R.,Wayne Smith C.,Wu H.,Sheikh-Hamad D.,&Sun Y..(2016).Ghrelin receptor regulates adipose tissue inflammation in aging.Aging,8(1),178-191.
MLA Lin L.,et al."Ghrelin receptor regulates adipose tissue inflammation in aging".Aging 8.1(2016):178-191.
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