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Anticancer Effects of Ginsenoside Rh2: A Systematic Review
He, Xin Ling1; Xu, Xiao Huang1; Shi, Jia Jie1; Huang, Mingqing2; Wang, Yitao1; Chen, Xiuping1; Lu, Jin Jian1,3
2022-01
Source PublicationCurrent Molecular Pharmacology
ISSN1874-4672
Volume15Issue:1Pages:179-189
Abstract

Background: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity. Objective: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product. Conclusion: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

KeywordCancer Cytotoxicity Ginseng Ginsenoside Rh2 Mechanism Natural Compound
DOI10.2174/1874467214666210309115105
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS IDWOS:000745544300011
Scopus ID2-s2.0-85123837944
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLu, Jin Jian
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China
3.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
He, Xin Ling,Xu, Xiao Huang,Shi, Jia Jie,et al. Anticancer Effects of Ginsenoside Rh2: A Systematic Review[J]. Current Molecular Pharmacology,2022,15(1):179-189.
APA He, Xin Ling,Xu, Xiao Huang,Shi, Jia Jie,Huang, Mingqing,Wang, Yitao,Chen, Xiuping,&Lu, Jin Jian.(2022).Anticancer Effects of Ginsenoside Rh2: A Systematic Review.Current Molecular Pharmacology,15(1),179-189.
MLA He, Xin Ling,et al."Anticancer Effects of Ginsenoside Rh2: A Systematic Review".Current Molecular Pharmacology 15.1(2022):179-189.
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