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Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
Choi, Joonho1,2; Yoon, Hyung Jun3; Park, Jae Hong4; Nakagami, Yukako5; Kubota, Chika6; Inada, Toshiya7; Kato, Takahiro A.8; Yang, Shu Yu9,10; Lin, Sih Ku11; Chong, Mian Yoon12; Avasthi, Ajit13; Grover, Sandeep13; Kallivayalil, Roy Abraham14; Tanra, Andi Jaylangkara15; Chee, Kok Yoon16; Xiang, Yu Tao17; Sim, Kang18; Javed, Afzal19; Tan, Chay Hoon20; Sartorius, Norman21; Kanba, Shigenobu8; Shinfuku, Naotaka22; Park, Yong Chon1; Park, Seon Cheol1,2
2022-01
Source PublicationJournal of Personalized Medicine
ISSN2075-4426
Volume12Issue:1
Abstract

The symptom heterogeneity of schizophrenia is consistent with Wittgenstein’s analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia. Furthermore, all the BPRS items were considered to be an ordered categorical variable ranging in value from 1–7. Motor retardation was situated most centrally within the BPRS network structure, followed by depressive mood and unusual thought content. Contrastingly, hallucinatory behavior was situated least centrally within the network structure. Using a community detection algorithm, the BPRS items were organized into positive, negative, and general symptom clusters. Overall, DSM symptoms were not more central than non-DSM symptoms within the symptom network of Asian patients with schizophrenia. Thus, motor retardation, which results from the unmet needs associated with current antipsychotic medications for schizophrenia, may be a tailored treatment target for Asian patients with schizophrenia. Based on these findings, targeting non-dopamine systems (glutamate, γ-aminobutyric acid) may represent an effective strategy with respect to precision medicine for psychosis.

KeywordBrief Psychiatric Rating Scale Heterogeneity Motor Retardation Network Analysis Precision Medicine Schizophrenia
DOI10.3390/jpm12010033
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaHealth Care Sciences & Services ; General & Internal Medicine
WOS SubjectHealth Care Sciences & Services ; Medicine, General & Internal
WOS IDWOS:000758429800001
Scopus ID2-s2.0-85122734838
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPark, Seon Cheol
Affiliation1.Department of Psychiatry, Hanyang University College of Medicine, Seoul, 04763, South Korea
2.Department of Psychiatry, Hanyang University Guri Hospital, Guri, 11923, South Korea
3.Department of Psychiatry, College of Medicine, Chosun University, Gwangju, 61452, South Korea
4.Department of Psychiatry, College of Medicine, Dong-A University, Busan, 47392, South Korea
5.Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan
6.Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan
7.Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
8.Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 819-0395, Japan
9.Department of Pharmacy, Taipei City Hospital, Fu Jen University, Taipei, 24205, Taiwan
10.School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, 242062, Taiwan
11.Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan
12.Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung & Chang Gung University School of Medicine, Taoyuan, 83301, Taiwan
13.Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
14.Department of Psychiatry, Pushpagiri Institute of Medical Sciences, Tiruvalla, 689101, India
15.Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia
16.Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital, Kuala Lumpur, 50586, Malaysia
17.Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, 820006, Macao
18.Institute of Mental Health, Buangkok Green Medical Park, Singapore, 539747, Singapore
19.Pakistan Psychiatric Research Centre, Fontain House, Lahore, 1317, Pakistan
20.Department of Pharmacology, National University of Singapore, Singapore, 119244, Singapore
21.Association for the Improvement of Mental Health Programmes, Geneva, 1211, Switzerland
22.Department of Social Welfare, School of Human Sciences, Seinan Gakuin University, Fukuoka, 814-8511, Japan
Recommended Citation
GB/T 7714
Choi, Joonho,Yoon, Hyung Jun,Park, Jae Hong,et al. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics[J]. Journal of Personalized Medicine,2022,12(1).
APA Choi, Joonho.,Yoon, Hyung Jun.,Park, Jae Hong.,Nakagami, Yukako.,Kubota, Chika.,Inada, Toshiya.,Kato, Takahiro A..,Yang, Shu Yu.,Lin, Sih Ku.,Chong, Mian Yoon.,Avasthi, Ajit.,Grover, Sandeep.,Kallivayalil, Roy Abraham.,Tanra, Andi Jaylangkara.,Chee, Kok Yoon.,Xiang, Yu Tao.,Sim, Kang.,Javed, Afzal.,Tan, Chay Hoon.,...&Park, Seon Cheol.(2022).Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics.Journal of Personalized Medicine,12(1).
MLA Choi, Joonho,et al."Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics".Journal of Personalized Medicine 12.1(2022).
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