UM  > Institute of Chinese Medical Sciences
Melamine Impairs Renal and Vascular Function in Rats
Tian X.Y.1; Wong W.T.1; Lau C.W.1; Wang Y.-X.1; Cheang W.S.1; Liu J.1; Lu Y.1; Huang H.1; Xia Y.1; Chen Z.Y.1; Mok C.-S.2; Lau C.-M.2; Huang Y.1
2016-06-21
Source PublicationScientific Reports
ISSN20452322
Volume6
Abstract

Melamine incident, linked to nephrotoxicity and kidney stone in infants previously exposed to melamine-contaminated milk products, was unprecedentedly grave in China in 2008 as little was known about the mechanistic process leading to renal dysfunction in affected children. This study investigates whether neonatal ingestion of melamine leads to renal and vascular dysfunction in adulthood; and whether ingestion of melamine in pregnant rats leads to renal dysfunction in their offspring. A combination of approaches employed includes functional studies in rat renal arteries, renal blood flow measurement by functional magnetic resonance imaging, assay for pro-inflammatory and fibrotic biomarkers, immunohistochemistry, and detection of plasma and renal melamine. We provide mechanistic evidence showing for the first time that melamine reduces renal blood flow and impairs renal and vascular function associated with overexpression of inflammatory markers, transforming growth factor-β1, bone morphogenic protein 4 and cyclooxygenase-2 in kidney and renal vasculature. Melamine also induces renal inflammation and fibrosis. More importantly, melamine causes nephropathies in offsprings from pregnant rat exposed to melamine during pregnancy, as well as in neonatal rat exposed to melamine afterbirth, thus supporting the clinical observations of kidney stone and acute renal failure in infants consuming melamine-contaminated milk products.

DOI10.1038/srep28041
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000378235000001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chinese University of Hong Kong
2.Hong Kong Government
Recommended Citation
GB/T 7714
Tian X.Y.,Wong W.T.,Lau C.W.,et al. Melamine Impairs Renal and Vascular Function in Rats[J]. Scientific Reports,2016,6.
APA Tian X.Y.,Wong W.T.,Lau C.W.,Wang Y.-X.,Cheang W.S.,Liu J.,Lu Y.,Huang H.,Xia Y.,Chen Z.Y.,Mok C.-S.,Lau C.-M.,&Huang Y..(2016).Melamine Impairs Renal and Vascular Function in Rats.Scientific Reports,6.
MLA Tian X.Y.,et al."Melamine Impairs Renal and Vascular Function in Rats".Scientific Reports 6(2016).
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