UM  > Institute of Chinese Medical Sciences
Melamine Impairs Renal and Vascular Function in Rats
Tian X.Y.1; Wong W.T.1; Lau C.W.1; Wang Y.-X.1; Cheang W.S.1; Liu J.1; Lu Y.1; Huang H.1; Xia Y.1; Chen Z.Y.1; Mok C.-S.2; Lau C.-M.2; Huang Y.1
Source PublicationScientific Reports

Melamine incident, linked to nephrotoxicity and kidney stone in infants previously exposed to melamine-contaminated milk products, was unprecedentedly grave in China in 2008 as little was known about the mechanistic process leading to renal dysfunction in affected children. This study investigates whether neonatal ingestion of melamine leads to renal and vascular dysfunction in adulthood; and whether ingestion of melamine in pregnant rats leads to renal dysfunction in their offspring. A combination of approaches employed includes functional studies in rat renal arteries, renal blood flow measurement by functional magnetic resonance imaging, assay for pro-inflammatory and fibrotic biomarkers, immunohistochemistry, and detection of plasma and renal melamine. We provide mechanistic evidence showing for the first time that melamine reduces renal blood flow and impairs renal and vascular function associated with overexpression of inflammatory markers, transforming growth factor-β1, bone morphogenic protein 4 and cyclooxygenase-2 in kidney and renal vasculature. Melamine also induces renal inflammation and fibrosis. More importantly, melamine causes nephropathies in offsprings from pregnant rat exposed to melamine during pregnancy, as well as in neonatal rat exposed to melamine afterbirth, thus supporting the clinical observations of kidney stone and acute renal failure in infants consuming melamine-contaminated milk products.

URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000378235000001
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chinese University of Hong Kong
2.Hong Kong Government
Recommended Citation
GB/T 7714
Tian X.Y.,Wong W.T.,Lau C.W.,et al. Melamine Impairs Renal and Vascular Function in Rats[J]. Scientific Reports,2016,6.
APA Tian X.Y.,Wong W.T.,Lau C.W.,Wang Y.-X.,Cheang W.S.,Liu J.,Lu Y.,Huang H.,Xia Y.,Chen Z.Y.,Mok C.-S.,Lau C.-M.,&Huang Y..(2016).Melamine Impairs Renal and Vascular Function in Rats.Scientific Reports,6.
MLA Tian X.Y.,et al."Melamine Impairs Renal and Vascular Function in Rats".Scientific Reports 6(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tian X.Y.]'s Articles
[Wong W.T.]'s Articles
[Lau C.W.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tian X.Y.]'s Articles
[Wong W.T.]'s Articles
[Lau C.W.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tian X.Y.]'s Articles
[Wong W.T.]'s Articles
[Lau C.W.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.