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Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective
Chen, Yu Chi1; Shi, Wei1; Shi, Jia Jie1; Lu, Jin Jian1,2,3
2022-01
Source PublicationJournal of Cancer Research and Clinical Oncology
ISSN0171-5216
Volume148Issue:1
Abstract

CD47, a transmembrane protein, acts as a “do not eat me” signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling the tumor cells to escape from macrophage-mediated phagocytosis. Several clinical trials with CD47 targeting agents are underway and have achieved impressive results preliminarily. However, hematotoxicity (particularly anemia) has emerged as the most common side effect that cannot be neglected. In the development of CD47 targeting agents, various methods have been used to mitigate this toxicity. In this review, we summarized five strategies used to alleviate CD47 blockade-induced hematotoxicity, as follows: change in the mode of administration; dual targeting bispecific antibodies of CD47; CD47 antibodies/SIRPα fusion proteins with negligible red blood cell binding; anti-SIRPα antibodies; and glutaminyl-peptide cyclotransferase like inhibitors. With these strategies, the development of CD47 targeting agents can be improved.

KeywordAnemia Cd47/sirpα Immunotherapy Macrophages Phagocytosis Checkpoint
DOI10.1007/s00432-021-03815-z
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000704470200001
Scopus ID2-s2.0-85116498019
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Social Sciences
Institute of Chinese Medical Sciences
Corresponding AuthorShi, Jia Jie; Lu, Jin Jian
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao
3.MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  Faculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Chen, Yu Chi,Shi, Wei,Shi, Jia Jie,et al. Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective[J]. Journal of Cancer Research and Clinical Oncology,2022,148(1).
APA Chen, Yu Chi,Shi, Wei,Shi, Jia Jie,&Lu, Jin Jian.(2022).Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective.Journal of Cancer Research and Clinical Oncology,148(1).
MLA Chen, Yu Chi,et al."Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective".Journal of Cancer Research and Clinical Oncology 148.1(2022).
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