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Metal-free bioorthogonal click chemistry in cancer theranostics
Wu, Dan1; Yang, Kuikun2; Zhang, Zhankui3; Feng, Yunxuan4; Rao, Lang5; Chen, Xiaoyuan6; Yu, Guocan7
2022-02-21
Source PublicationChemical Society reviews
ISSN0306-0012
Volume51Issue:4Pages:1336-1376
Abstract

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems. Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and specifically take place in a mild physiological milieu without perturbing inherent biochemical processes. Attributed to their high selectivity and efficiency, bioorthogonal reactions can significantly decrease background signals in bioimaging. Compared with metal-catalyzed bioorthogonal click reactions, metal-free click reactions are more biocompatible without the metal catalyst-induced cytotoxicity. Although a great number of bioorthogonal chemistry-based strategies have been reported for cancer theranostics, a comprehensive review is scarce to highlight the advantages of these strategies. In this review, recent progress in cancer theranostics guided by metal-free bioorthogonal click chemistry will be depicted in detail. The elaborate design as well as the advantages of bioorthogonal chemistry in tumor theranostics are summarized and future prospects in this emerging field are emphasized.

DOI10.1039/d1cs00451d
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000744620900001
Scopus ID2-s2.0-85125020623
Fulltext Access
FWCI3.1106448
Citation statistics
Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorWu, Dan; Rao, Lang; Chen, Xiaoyuan
Affiliation1.College of Materials Science and Engineering, Zhejiang University of Technology Hangzhou, 310014, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau 999078, P. R. China
3.College of Materials Science and Engineering, Zhejiang University of Technology Hangzhou, 310014, China
4.Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, 100084, China
5.Institute of Biomedical Health Technology and Engineering, Shenzhen, Shenzhen Bay Laboratory, 518132, China
6.Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, 117597, Singapore
7.Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, 100084, China
Recommended Citation
GB/T 7714
Wu, Dan,Yang, Kuikun,Zhang, Zhankui,et al. Metal-free bioorthogonal click chemistry in cancer theranostics[J]. Chemical Society reviews,2022,51(4):1336-1376.
APA Wu, Dan,Yang, Kuikun,Zhang, Zhankui,Feng, Yunxuan,Rao, Lang,Chen, Xiaoyuan,&Yu, Guocan.(2022).Metal-free bioorthogonal click chemistry in cancer theranostics.Chemical Society reviews,51(4),1336-1376.
MLA Wu, Dan,et al."Metal-free bioorthogonal click chemistry in cancer theranostics".Chemical Society reviews 51.4(2022):1336-1376.
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