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Antibacterial property of a gradient Cu-bearing titanium alloy by laser additive manufacturing
Fan, Dong Yang1; Yi, Zhe1; Feng, Xu1; Tian, Wen Zhi1; Xu, Da Ke2; Cristino Valentino, A. M.3; Wang, Qiang1; Sun, Hong Chen1
2022-02-01
Source PublicationRare Metals
ISSN1001-0521
Volume41Issue:2Pages:580-593
Abstract

Streptococcus mutans (S. mutans) is the most common cariogenic bacteria and causes caries by forming biofilms. A novel gradient Cu-bearing titanium alloy (TC4-5Cu/TC4) was manufactured using selective laser melting (SLM) technology for dental applications, which is anticipated to inhibit the formation of biofilm. In this study, the released concentration of copper ions in both minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was tested in order to assess the antibacterial property of the alloy against planktonic S. mutans, and the antibacterial and antibiofilm efficiencies of TC4-5Cu/TC4 alloy against sessile S. mutans were evaluated via quantitative antibacterial tests and biofilm determination. Reverse transcription polymerase chain reaction (RT-PCR) was performed to analyze the expression of biofilm-related genes (gtfB, gtfC, gtfD, ftf and gbpB) and acid production-related gene (ldh). The results suggested that the MIC and MBC of Cu were much higher than the release concentration of copper ions of the alloy, which was consistent with the lack of antibacterial effect against planktonic bacteria. On the contrary, TC4-5Cu/TC4 alloy exhibited significant bactericidal property against the sessile bacteria and efficient biofilm-restrained ability, and all genes detected in this research were down-regulated. The results indicated that the TC4-5Cu/TC4 alloy suppressed biofilm formation and the sessile bacterial viability by down-regulating biofilm-related genes.

KeywordAntibacterial Property Biofilm Copper Streptococcus Mutans Titanium Alloys
DOI10.1007/s12598-021-01826-w
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000700994100001
Scopus ID2-s2.0-85115742719
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF ELECTROMECHANICAL ENGINEERING
Corresponding AuthorWang, Qiang; Sun, Hong Chen
Affiliation1.School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110002, China
2.Shenyang National Laboratory for Materials Science, Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education), School of Materials Science and Engineering, Northeastern University, Shenyang, 110819, China
3.Department of Electromechanical Engineering, University of Macau, Taipa, Avenida da Universidade, Macao
Recommended Citation
GB/T 7714
Fan, Dong Yang,Yi, Zhe,Feng, Xu,et al. Antibacterial property of a gradient Cu-bearing titanium alloy by laser additive manufacturing[J]. Rare Metals,2022,41(2):580-593.
APA Fan, Dong Yang,Yi, Zhe,Feng, Xu,Tian, Wen Zhi,Xu, Da Ke,Cristino Valentino, A. M.,Wang, Qiang,&Sun, Hong Chen.(2022).Antibacterial property of a gradient Cu-bearing titanium alloy by laser additive manufacturing.Rare Metals,41(2),580-593.
MLA Fan, Dong Yang,et al."Antibacterial property of a gradient Cu-bearing titanium alloy by laser additive manufacturing".Rare Metals 41.2(2022):580-593.
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