UM  > Faculty of Health Sciences  > DEPARTMENT OF PHARMACEUTICAL SCIENCES
Residential Collegefalse
Status已發表Published
The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio)
Bian, Yaqi1; Wang, Xiufen1; Liang, Jian hui2; Li, Lin1; Wu, Xue1; Tang, Benqin1,3; Leung, George Pak Heng4; Lee, Simon Ming Yuen1
2022-03-08
Source PublicationProgress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN0278-5846
Volume113
Abstract

Background: Accumulating evidence suggest that behavioral sensitization is involved in the process of drug addiction. Zebrafish are sensitive to a variety of addictive drugs and are thus suitable for the study of behavioral sensitization. However, in contrast to mature rodent models of behavioral sensitization, how this phenomenon manifests in aquatic organisms, especially zebrafish, is largely unknown. In this study, we developed a morphine-induced behavioral sensitization adult zebrafish model and performed a preliminary investigation of the underlying mechanisms. Methods: Behavioral sensitization was established in zebrafish by observing their behavior after treatment and challenge with morphine. The effect of morphine was evaluated by a behavioral locomotor test. Different doses of morphine and withdrawal times were used to evaluate the establishment of the behavioral sensitization model. Results: Hyperlocomotion was induced after administration of morphine in adult zebrafish. After withdrawing the drug for a period, challenge with low-dose morphine evoked behavioral sensitization in zebrafish acutely pre-treated with morphine. Low-dose morphine failed to induce behavioral sensitization in zebrafish if the withdrawal time was less than 5 days or more than 7 days. Morphine induced behavioral sensitization in zebrafish may involve dopaminergic, glutamatergic and opioid systems. Conclusion: A single low-dose of morphine could induce behavioral sensitization in zebrafish acutely pre-treated with morphine, and this phenomenon was highly correlated with drug dose and withdrawal time. These findings suggest that zebrafish is a suitable model for the study of behavioral sensitization.

KeywordBehavioral Sensitization Drug Addiction Morphine Zebrafish
DOI10.1016/j.pnpbp.2021.110456
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000714736100001
Scopus ID2-s2.0-85117719891
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorLiang, Jian hui; Lee, Simon Ming Yuen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, 100083, China
3.Department of Medical Science, Shunde Polytechnic, Foshan, China
4.Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bian, Yaqi,Wang, Xiufen,Liang, Jian hui,et al. The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio)[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry,2022,113.
APA Bian, Yaqi,Wang, Xiufen,Liang, Jian hui,Li, Lin,Wu, Xue,Tang, Benqin,Leung, George Pak Heng,&Lee, Simon Ming Yuen.(2022).The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio).Progress in Neuro-Psychopharmacology and Biological Psychiatry,113.
MLA Bian, Yaqi,et al."The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio)".Progress in Neuro-Psychopharmacology and Biological Psychiatry 113(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Bian, Yaqi]'s Articles
[Wang, Xiufen]'s Articles
[Liang, Jian hui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Bian, Yaqi]'s Articles
[Wang, Xiufen]'s Articles
[Liang, Jian hui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Bian, Yaqi]'s Articles
[Wang, Xiufen]'s Articles
[Liang, Jian hui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.