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Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)
Cheng, Qian1; Xu, Meng1; Sun, Chen1; Yang, Kuikun1; Yang, Zhiqing1; Li, Junyan1; Zheng, Jun2; Zheng, Ying1,2; Wang, Ruibing2,3
2022-03-07
Source PublicationMaterials horizons
ISSN2051-6347
Volume9Issue:3Pages:934-941
Abstract

Bacterial infection has become a global concern owing to the significant morbidity and mortality. Although the phagocytosis of bacteria by immune cells acts as the front line to protect human body from invading pathogens, the relatively slow encounter and insufficient capture of bacteria by immune cells often lead to an inefficient clearance of pathogens. Herein, a supramolecular artificial receptor-modified macrophage (SAR-Macrophage) was developed to enhance the recognition and latch of bacteria in the systemic circulation, mediated via strong and multipoint host-guest interactions between the artificial receptors (cucurbit[7]uril) on the macrophage and the guest ligands (adamantane) selectively anchored on Escherichia coli (E. coli). As a result, the SAR-Macrophage could significantly accelerate the recognition of E. coli, catch and internalize more pathogens, which subsequently induced the M1 polarization of macrophages to generate ROS and effectively kill the intracellular bacteria. Therefore, the SAR-Macrophage represents a simple, yet powerful anti-bacterial approach.

DOI10.1039/d1mh01813b
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS IDWOS:000743176800001
Scopus ID2-s2.0-85124614498
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding AuthorWang, Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. rwang@um.edu.mo
2.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationFaculty of Health Sciences;  Institute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cheng, Qian,Xu, Meng,Sun, Chen,et al. Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)[J]. Materials horizons,2022,9(3):934-941.
APA Cheng, Qian,Xu, Meng,Sun, Chen,Yang, Kuikun,Yang, Zhiqing,Li, Junyan,Zheng, Jun,Zheng, Ying,&Wang, Ruibing.(2022).Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage).Materials horizons,9(3),934-941.
MLA Cheng, Qian,et al."Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)".Materials horizons 9.3(2022):934-941.
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