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Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy
Yan, Jie1,2; Wang, Guohao1,2; Xie, Lisi1,2; Tian, Hao1,2; Li, Jie1,2; Li, Bei1,2; Sang, Wei1,2; Li, Wenxi1,2; Zhang, Zhan1,2; Dai, Yunlu1,2
2022-03-10
Source PublicationAdvanced Materials
ISSN0935-9648
Volume34Issue:10
Abstract

Radiotherapy, a mainstay of first-line cancer treatment, suffers from its high-dose radiation-induced systemic toxicity and radioresistance caused by the immunosuppressive tumor microenvironment. The synergy between radiosensitization and immunomodulation may overcome these obstacles for advanced radiotherapy. Here, the authors propose a radiosensitization cooperated with stimulator of interferon genes (STING) pathway activation strategy by fabricating a novel lanthanide-doped radiosensitizer-based metal-phenolic network, NaGdF:Nd@NaLuF@PEG-polyphenol/Mn (DSPM). The amphiphilic PEG-polyphenol successfully coordinates with NaGdF:Nd@NaLuF (radiosensitizer) and Mn via robust metal-phenolic coordination. After cell internalization, the pH-responsive disassembly of DSPM triggers the release of their payloads, wherein radiosensitizer sensitizes cancer cells to X-ray and Mn promote STING pathway activation. This radiosensitizer-based DSPM remarkably benefits dendritic cell maturation, anticancer therapeutics in primary tumors, accompanied by robust systemic immune therapeutic performance against metastatic tumors. Therefore, a powerful radiosensitization with STING pathway activation mediated immunostimulation strategy is highlighted here to optimize cancer radiotherapy.

KeywordLanthanide-doped Radiosensitizers Manganese Metal–phenolic Networks Radiosensitization Effects Stimulator Of Interferon Genes Pathways
DOI10.1002/adma.202105783
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000748789500001
Scopus ID2-s2.0-85123712951
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDai, Yunlu
Affiliation1.Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, 999078, Macao
2.MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macao
First Author AffilicationCancer Centre;  University of Macau
Corresponding Author AffilicationCancer Centre;  University of Macau
Recommended Citation
GB/T 7714
Yan, Jie,Wang, Guohao,Xie, Lisi,et al. Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy[J]. Advanced Materials,2022,34(10).
APA Yan, Jie,Wang, Guohao,Xie, Lisi,Tian, Hao,Li, Jie,Li, Bei,Sang, Wei,Li, Wenxi,Zhang, Zhan,&Dai, Yunlu.(2022).Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy.Advanced Materials,34(10).
MLA Yan, Jie,et al."Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy".Advanced Materials 34.10(2022).
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