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Stability of nanosuspensions in drug delivery
Yancai Wang1,2; Ying Zheng2; Ling Zhang3; Qiwei Wang4; Dianrui Zhang4
Source PublicationJournal of Controlled Release

Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth. Despite extensive research on nanosuspension technology, stability remains a limitation for pharmaceutical or industrial applications of nanosuspensions. Furthermore, the empirical relationship between stabilizer efficacy and nanosuspension stability has not been well characterized. This review focuses on the issue of nanosuspension stability in drug delivery to present the state of the art of nanosuspensions. Therefore, this review will discuss unstable suspensions, methods and guidelines for selecting and optimizing stabilizers, approaches for enhancing stability, and other factors that influence nanosuspension stability. This review could serve as a reference for the educated selection of a stabilizer for a specific drug candidate and the optimization of the operational parameters for nanosuspension formulation, rather than the currently practiced trial-and-error approach.

KeywordNanosuspensions Stability Stabilizers Aggregation Crystalline Transformation
Indexed BySCIE
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000328492800055
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Cited Times [WOS]:279   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Chemistry and Pharmaceutical Engineering, Shandong Polytechnic University, Jinan 250353, PR China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, PR China
3.Library, Shandong University of Finance and Economics, Jinan 250014, PR China
4.College of Pharmacy, Shandong University, Jinan 250012, PR China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yancai Wang,Ying Zheng,Ling Zhang,et al. Stability of nanosuspensions in drug delivery[J]. Journal of Controlled Release,2013,172(3):1126-1141.
APA Yancai Wang,Ying Zheng,Ling Zhang,Qiwei Wang,&Dianrui Zhang.(2013).Stability of nanosuspensions in drug delivery.Journal of Controlled Release,172(3),1126-1141.
MLA Yancai Wang,et al."Stability of nanosuspensions in drug delivery".Journal of Controlled Release 172.3(2013):1126-1141.
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