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Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen
Li, Bin1,2; Guo, Libin3,4; Chen, Meijuan5; Guo, Yuanyuan5; Ge, Lilin1,2; Kwok, Hang Fai3,4
2022-04-15
Source PublicationBiosensors and Bioelectronics
ISSN0956-5663
Volume202
Abstract

Photoelectrochemical immunoassays/immunosensors have been employed for biomarker detection, but most are lack of high-efficiency photo-electron transfer nanomaterials for widespread utilization. Herein we synthesized single-atom platinum-anchored ZnCdS nanostructures to construct an innovative photoelectrochemical (PEC) immunosensor for photocurrent determination of prostate-specific antigen (PSA). Improvement of the photocurrent on the sensing interface derived from the ion-exchange reaction between cupric oxide nanoparticle (CuO NP)-labeled secondary antibody and single-atom platinum-anchored ZnCdS. The experimental results showed that the doping of zinc ions and atomically dispersed platinum into CdS could significantly enhance the photocurrent, which further improved the sensitivity of immunoassay. Specifically, upon sensing the target PSA, a CuO-labeled detection antibody was introduced by sandwich immunoreaction and numerous copper ions (Cu) were released from CuO by acid to participate in the ion-exchange reaction. Thereafter, the ion-exchange reaction between Cu ions and single-atom platinum-anchored ZnCdS resulted in the quenching of the photocurrent from single-atom platinum-anchored ZnCdS owing to weak photoactive material CuS formation. Under optimized conditions, single-atom platinum-anchored ZnCdS-based photoelectrochemical immunoassay gave good PEC signals toward PSA from 1.0 to 10000 pg/mL with a limit of detection of 0.22 pg/mL. Additionally, good repeatability, intermediate precision, strong anti-interference and high accuracy (relative to commercialized ELISA kit) for the measurement of human serum specimens were acquired. Importantly, use of single-atom platinum-anchored ZnCdS can provide an important idea for early tumor screening and diagnosis.

KeywordAtomic-level Distribution Effective Charge-separation Ion-exchange Reaction Photoelectrochemical Immunoassays Zn0.5cd0.5s
DOI10.1016/j.bios.2022.114006
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS SubjectBiophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS IDWOS:000796807600003
Scopus ID2-s2.0-85123729149
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Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionMinistry of Education Frontiers Science Center for Precision Oncology, University of Macau
Faculty of Health Sciences
Cancer Centre
Co-First AuthorLi, Bin
Corresponding AuthorGe, Lilin; Kwok, Hang Fai
Affiliation1.Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.Faculty of Health Sciences, University of Macau, Avenida da Univesidade, Taipa, Macao
3.Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao
4.MoE Frontiers Science Center for Precision Oncology, University of Macau, Avenida de Universidade, Taipa, Macao
5.Lab of Antitumor Mechanism Investigation of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences;  Cancer Centre;  University of Macau
Recommended Citation
GB/T 7714
Li, Bin,Guo, Libin,Chen, Meijuan,et al. Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen[J]. Biosensors and Bioelectronics,2022,202.
APA Li, Bin,Guo, Libin,Chen, Meijuan,Guo, Yuanyuan,Ge, Lilin,&Kwok, Hang Fai.(2022).Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen.Biosensors and Bioelectronics,202.
MLA Li, Bin,et al."Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen".Biosensors and Bioelectronics 202(2022).
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