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USP13: Multiple Functions and Target Inhibition
Li, Xiaolong1; Yang, Ge1; Zhang, Wenyao1; Qin, Biying1; Ye, Zifan1; Shi, Huijing1; Zhao, Xinmeng1; Chen, Yihang1; Song, Bowei1; Mei, Ziqing2; Zhao, Qi3; Wang, Feng1
2022-04-04
Source PublicationFrontiers in Cell and Developmental Biology
ISSN2296-634X
Volume10
Abstract

As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA damage response, and endoplasmic reticulum-associated degradation (ERAD), by regulating the deubiquitination of diverse key substrate proteins. Thus, dysregulation of USP13 can give rise to the occurrence and development of plenty of diseases, in particular malignant tumors. Given its implications in the stabilization of disease-related proteins and oncology targets, considerable efforts have been committed to the discovery of inhibitors targeting USP13. Here, we summarize an overview of the recent advances of the structure, function of USP13, and its relations to diseases, as well as discovery and development of inhibitors, aiming to provide the theoretical basis for investigation of the molecular mechanism of USP13 action and further development of more potent druggable inhibitors.

KeywordDeubiquitination Disease Inhibitor Structure Ubiquitin-specific Protease 13
DOI10.3389/fcell.2022.875124
URLView the original
Language英語English
Scopus ID2-s2.0-85128456233
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang, Feng
Affiliation1.Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing, China
2.School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China
3.University of Macau, China
Recommended Citation
GB/T 7714
Li, Xiaolong,Yang, Ge,Zhang, Wenyao,et al. USP13: Multiple Functions and Target Inhibition[J]. Frontiers in Cell and Developmental Biology,2022,10.
APA Li, Xiaolong,Yang, Ge,Zhang, Wenyao,Qin, Biying,Ye, Zifan,Shi, Huijing,Zhao, Xinmeng,Chen, Yihang,Song, Bowei,Mei, Ziqing,Zhao, Qi,&Wang, Feng.(2022).USP13: Multiple Functions and Target Inhibition.Frontiers in Cell and Developmental Biology,10.
MLA Li, Xiaolong,et al."USP13: Multiple Functions and Target Inhibition".Frontiers in Cell and Developmental Biology 10(2022).
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