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Emerging pharmacotherapy for inflammatory bowel diseases
Luo, Hua1; Cao, Guiqing2; Luo, Chun1,2; Tan, Dechao1; Vong, Chi Teng1; Xu, Yinyue3,4; Wang, Sicen3,4; Lu, Haitao5; Wang, Yitao1; Jing, Wanghui1,4
2022-04-01
Source PublicationPharmacological Research
ISSN1043-6618
Volume178
Abstract

Inflammatory bowel disease (IBD) refers to a gamut of disorders that are characterized by chronic intestinal inflammation, including ulcerative colitis (UC) and Crohn's disease (CD), which often leads to mucosal ulceration and progressive loss of intestinal function. The etiopathogenesis of IBD has not been completely clarified, although multiple factors involving genetic modifications, host immune dysfunction, intestinal dysbiosis and environmental effects have been implicated. Currently, pharmacotherapies including both non-targeted and targeted biological agents are widely used for the clinical treatment of IBD. In addition, novel therapeutic approaches that target the intestinal microorganisms, such as fecal microbiota transplantation, antibiotics, probiotics and microbial metabolite inhibitors, are also under development. However, these treatments are either accompanied by side effects or cannot achieve complete clinical remission when used alone. The efficacy and safety of drugs are currently a clinical challenge. Thus, advanced drug delivery systems are needed for targeted delivery of drugs to the inflammatory sites and avoid absorption by healthy tissues. In this review, we have summarized the latest research on the pathogenesis of IBD and the emerging pharmacotherapies, and discussed potential therapeutic targets for innovative therapies.

KeywordEmerging Pharmacotherapy Ibd Molecular Pathogenesis Therapeutic Targets
DOI10.1016/j.phrs.2022.106146
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000794346100006
Scopus ID2-s2.0-85125547030
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLu, Haitao; Wang, Yitao; Jing, Wanghui
Affiliation1.Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Macao
2.The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China
3.School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China
4.Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an, China
5.Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Laboratory of Functional Metabolomics Science, Shanghai Jiao Tong University, Shanghai, 200240, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Luo, Hua,Cao, Guiqing,Luo, Chun,et al. Emerging pharmacotherapy for inflammatory bowel diseases[J]. Pharmacological Research,2022,178.
APA Luo, Hua,Cao, Guiqing,Luo, Chun,Tan, Dechao,Vong, Chi Teng,Xu, Yinyue,Wang, Sicen,Lu, Haitao,Wang, Yitao,&Jing, Wanghui.(2022).Emerging pharmacotherapy for inflammatory bowel diseases.Pharmacological Research,178.
MLA Luo, Hua,et al."Emerging pharmacotherapy for inflammatory bowel diseases".Pharmacological Research 178(2022).
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