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Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis
Chen, Shiyun1; Chen, Zhejie1; Wang, Yi2; Hao, Wei1; Yuan, Qin1; Zhou, Hefeng3; Gao, Caifang1; Wang, Yitao1; Wu, Xu2; Wang, Shengpeng1
2021-11
Source PublicationJournal of Advanced Research
ISSN2090-1232
Volume40Pages:263-276
Abstract

Introduction: Ulcerative colitis (UC) is a chronic recurrent idiopathic disease characterized by damage to the colonic epithelial barrier and disruption of inflammatory homeostasis. At present, there is no curative therapy for UC, and the development of effective and low-cost therapies is strongly advocated. Objectives: Multiple lines of evidence support that tannic acid (TA) and berberine (BBR), two active ingredients derived from Chinese herb pair (Rhei Radix et Rhizoma and Coptidis Rhizoma), have promising therapeutic effects on colonic inflammation. This study aims to develop a targeted delivery system based on BBR/TA-based self-assemblies for the treatment of UC. Methods: TA and BBR self-assemblies were optimized, and hyaluronic acid (HA) was coated to achieve targeted colon delivery via HA-cluster of differentiation 44 (CD44) interactions. The system was systematically characterized and dextran sodium sulfate (DSS)-induced mouse colitis model was further used to investigate the biodistribution behavior, effect and mechanism of the natural system. Results: TA and BBR could self-assemble into stable particles (TB) and HA-coated TB (HTB) further increased cellular uptake and accumulation in inflamed colon lesions. Treatment of HTB inhibited pro-inflammatory cytokine levels, restored expression of tight junction-associated proteins and recovered gut microbiome alteration, thereby exerting anti-inflammatory effects against DSS-induced acute colitis. Conclusion: Our targeted strategy may provide a convenient and powerful platform for UC and reveal new modes of application of herbal combinations.

KeywordBerberine Drug Delivery Gut Microbiome Tannin Acid Ulcerative Colitis
DOI10.1016/j.jare.2021.11.017
URLView the original
Language英語English
Scopus ID2-s2.0-85121979066
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWu, Xu; Wang, Shengpeng
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
3.Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Shiyun,Chen, Zhejie,Wang, Yi,et al. Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis[J]. Journal of Advanced Research,2021,40:263-276.
APA Chen, Shiyun,Chen, Zhejie,Wang, Yi,Hao, Wei,Yuan, Qin,Zhou, Hefeng,Gao, Caifang,Wang, Yitao,Wu, Xu,&Wang, Shengpeng.(2021).Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis.Journal of Advanced Research,40,263-276.
MLA Chen, Shiyun,et al."Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis".Journal of Advanced Research 40(2021):263-276.
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