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ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB
Won, Minho1,2; Park, Kyeong Ah1; Kim, Sup3; Ju, Eunjin1; Ko, Youngbok4; Yoo, Heonjong4; Ro, Hyunju5; Lee, Jaeseob6; Oh, Junseo6; Lee, Eun Gyo2; Kim, Sang Yean7; Nam, Suk Woo7; Shen, Han Ming8; Yeo, Min Kyung9; Kim, Jin Man9; Hur, Gang Min1
2021
Source PublicationCell Death and Differentiation
ISSN1350-9047
Abstract

In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of the signaling complex from complex-I to death-inducing complex-II. Here, we report that ankyrin repeat domain 13a (ANKRD13a) acts as a novel component of complex-II to set a higher signal threshold for the cytotoxic potential of TNF. ANKRD13a deficiency is sufficient to turn the response to TNF from survival to death by promoting the formation of complex-II without affecting NF-κB activation. ANKRD13a binds to ubiquitinated-RIP1 via its UIM, and subsequently limits the association of FADD and caspase-8 with RIP1. Moreover, high ANKRD13a expression is inversely correlated with apoptotic phenotypes in ovarian cancer tissues and is associated with poor prognosis. Our work identifies ANKRD13a as a novel gatekeeper of the early cell-death checkpoint, which may function as part of an escape mechanism from cell death in some cancers.

DOI10.1038/s41418-021-00906-9
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000722967200001
Scopus ID2-s2.0-85120045680
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHur, Gang Min
Affiliation1.Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea
2.Biotechnology Process Engineering Center, Korea Research Institute of Bioscience & Biotechnology, Cheongju, 28116, South Korea
3.Department of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea
4.Department of Obstetrics and Gynecology, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea
5.Department of Biological Sciences, College of Biosciences and Biotechnology, Chungnam National University, Daejeon, 34134, South Korea
6.Department of Biomedical Science, Korea University Graduate School, Seoul, 02841, South Korea
7.Department of Pathology, College of Medicine, The Catholic University, Seoul, 06591, South Korea
8.Faculty of Health Sciences, University of Macau, Macao
9.Department of Pathology, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea
Recommended Citation
GB/T 7714
Won, Minho,Park, Kyeong Ah,Kim, Sup,et al. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB[J]. Cell Death and Differentiation,2021.
APA Won, Minho,Park, Kyeong Ah,Kim, Sup,Ju, Eunjin,Ko, Youngbok,Yoo, Heonjong,Ro, Hyunju,Lee, Jaeseob,Oh, Junseo,Lee, Eun Gyo,Kim, Sang Yean,Nam, Suk Woo,Shen, Han Ming,Yeo, Min Kyung,Kim, Jin Man,&Hur, Gang Min.(2021).ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.Cell Death and Differentiation.
MLA Won, Minho,et al."ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB".Cell Death and Differentiation (2021).
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