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Engineered exosomes: Desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies
Xu, Meng1; Feng, Tao1; Liu, Bowen1; Qiu, Fen1; Xu, Youhua2; Zhao, Yonghua1; Zheng, Ying1
2021
Source PublicationTheranostics
Volume11Issue:18Pages:8926-8944
Abstract

As extracellular vesicles secreted by cells, exosomes are intercellular signalosomes for cell communication and pharmacological effectors. Because of their special properties, including low toxicity and immunogenicity, biodegradability, ability to encapsulate endogenous biologically active molecules and cross the blood-brain barrier (BBB), exosomes have great therapeutic potential in cerebrovascular and neurodegenerative diseases. However, the poor targeting ability of natural exosomes greatly reduces the therapeutic effect. Using engineering technology, exosomes can obtain active targeting ability to accumulate in specific cell types and tissues by attaching targeting units to the membrane surface or loading them into cavities. In this review, we outline the improved targeting functions of bioengineered exosomes, tracing and imaging techniques, administration methods, internalization in the BBB, and therapeutic effects of exosomes in cerebrovascular and neurodegenerative diseases and further evaluate the clinical opportunities and challenges in this research field.

KeywordAdministration Routes Brain Targeting Cerebrovascular Disease Engineered Exosomes Neurological Disorders Tracking
DOI10.7150/thno.62330
URLView the original
Indexed BySCIE
Language英語English
Scopus ID2-s2.0-85114767096
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhao, Yonghua; Zheng, Ying
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,, Taipa, Macao
2.Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu, Meng,Feng, Tao,Liu, Bowen,et al. Engineered exosomes: Desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies[J]. Theranostics,2021,11(18):8926-8944.
APA Xu, Meng,Feng, Tao,Liu, Bowen,Qiu, Fen,Xu, Youhua,Zhao, Yonghua,&Zheng, Ying.(2021).Engineered exosomes: Desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies.Theranostics,11(18),8926-8944.
MLA Xu, Meng,et al."Engineered exosomes: Desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies".Theranostics 11.18(2021):8926-8944.
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